Quantification and Archiving of Pediatric Brain MRI as an Educational Resource

描述（由申请人提供）：我们的目标是开发一个电子系统来存档、可视化和量化脑mri，并将其与患者人口统计、临床和诊断信息联系起来。在本提案中，我们将初步尝试开发几个关键工具来建立这个数据库，最初的重点是儿科人群。具体来说，我们将创建一个试点数据库，使用从约翰霍普金斯医院获得的现有临床数据，PACS系统上有大量可用数据，以及JHU正常儿科数据库（lbam.med.jhmi.edu）。所有相关图像将归一化为共同的空间坐标，结合结构化的人口统计和临床信息，并去识别。然后，将图像分割成各种解剖结构，并对每一段的体积和强度进行量化；2)开发一个原型用户界面（基于AtlasView软件，www.mristudio.org），允许在数据库中导航，查看不同空间和对比度的多个图像，覆盖分割，访问量化，患者数据，人口统计和诊所信息。如果我们成功，这个电子档案和相关的量化工具将潜在地成为教育目的的重要来源，用于共享标准化研究信息和辅助放射学解释。

DESCRIPTION (provided by applicant): Our goal is to develop an electronic system to archive, visualize, and quantity brain MRIs, linked with patients demographic, clinic, and diagnostic information. In this proposal, we will perform initial attempts to develop several key tools to establish this database, initially focused on pediatric population. Specifically, we will ) Create a pilot database, using existing clinical data acquired in Johns Hopkins Hospital, plenty available on PACS systems, and the JHU normal pediatric database (lbam.med.jhmi.edu). All relevant images will be normalized to common spatial coordinates, combined with structured demographic and clinical information, and de-identified. Then, the images will be segmented into various anatomical structures and each segment will be quantified for volume and intensities; and 2) Develop a prototype user interface (based on AtlasView software, www.mristudio.org) that will allow to navigate in the database, to view multiple images in different spaces and contrasts, to overlay the segmentation, to access the quantification, patient data, demographic, and clinic information. If we succeed, this electronic archive and the associated quantification tools will potentially become an important source for educational purposes, for sharing standardized research information and for aiding radiologic interpretation.