Baylor Intellectual and Developmental Disabilities Research Center

贝勒医学院（BCM）智力和发育障碍研究中心（IDDRC）成立于1988年8月1日，并一直得到资助，最后一次资助更新于2004年7月1日。具体目标是：1)通过鼓励和集中研究IDD的病因、诊断、预防、发病机制和干预措施，加强BCM的智力残疾活动。2)通过改善中心研究人员之间的互动，以及继续开发和应用前沿技术，继续推动IDD研究的多学科方法。3)通过有效和高效的研究核心单元提高项目研究者的生产力，并促进转化研究工作。4)通过与中心研究人员的科学互动，并通过BCM-IDDRC核心为多学科方法提供基础设施，招募新的研究人员进入IDD研究领域。5)促进与贝勒大学以外的研究人员的科学和合作互动，这些研究人员已经表现出对研究和治疗IDD的主要承诺。研究项目将由行政核心(A)和七个研究核心提供支持：高通量基因组和RNA分析(B)，全基因组RNAi分析(C)，基因表达分析(包括神经病理学，共聚焦和RNA原位分析(D)，组织培养(E)，干细胞(F)，小鼠神经行为(G)和小鼠生理学(H)。共有教职工48人，其中研究项目调查员41人，研究项目73项。BCM-IDDRC的研究范围将包括以下十个主题领域：1)神经生物学，大脑发育的细胞和分子方面；2)先天代谢缺陷；3)疾病的遗传和表观遗传基础；4) IDD诊断筛查创新技术；5)动物模型的发病机制和开发和测试治疗；6)影响神经系统功能的通路；7) IDD的分子、行为和治疗研究，包括脆性X综合征、Angelman综合征、Prader-Willi综合征和Rett综合征；8)基因诊断人群临床表型的定义；9)攻击性、社会行为问题和刻板印象的研究；10)自闭症谱系障碍的神经生物学、遗传学、发病机制和药理学方法。

The Baylor College of Medicine (BCM) Intellectual and Developmental Disabilities Research Center (IDDRC) was established on August 1, 1988 and has been continuously funded with the last renewal of funding dated July 1, 2004. The specific objectives are: 1) To enhance intellectual disabilities activities at BCM by encouraging and focusing research efforts on etiology, diagnosis, prevention, pathogenesis, and intervention of IDD. 2) To continue to promote a multidisciplinary approach to IDD research by improving interactions among Center investigators, and by continuing to develop and to apply leading edge technologies. 3) To enhance the productivity of project investigators through effective and efficient research core units and to facilitate translational research efforts. 4) To recruit new investigators into the field of IDD research through scientific interactions with center investigators and by providing the infrastructure for a multidisciplinary approach through the BCM-IDDRC Cores. 5) To promote scientific and collaborative interactions with investigators outside Baylor who have demonstrated a major commitment to study and treat IDD. The research projects will be supported by the Administrative Core (A), and by seven research cores: High Throughput Genomic & RNA Analysis (B), Genome-Wide RNAi Analysis (C), Gene Expression Analysis which includes Neuropathology, Confocal, and RNA in situ (D), Tissue Culture (E), Stem Cell (F), Mouse Neurobehavior (G), and Mouse Physiology (H). There are 48 faculty participants, including 41 research project investigators and 73 research projects. The scope of research at the BCM-IDDRC will include the following ten topic areas: 1) Neurobiology, cellular & molecular aspects of brain development; 2) Inborn errors of metabolism; 3) Genetic & epigenetic basis of diseases; 4) Innovative technologies for diagnosis & screening IDD; 5) Animal models for pathogenesis & for developing and testing therapeutics; 6) Pathways that affect function of nervous system; 7) Molecular, behavioral & therapeutic studies in IDD including fragile X, Angelman, Prader-Willi, and Rett syndromes; 8) Definition of clinical phenotypes in genetically diagnosed populations; 9) Studies of aggression, social behavioral problems and stereotypies; and 10) Neurobiology, genetics, pathogenesis & pharmacological approaches in autism spectrum disorders.