Training Clinician Scientists in Neuroinfectious Disease

描述（由申请人提供）：这一新的竞争性申请要求支持在约翰霍普金斯大学建立一个神经传染病机构NRSA。神经系统感染是发病率和死亡率的主要原因，但目前该国没有其他针对神经系统感染的培训方案。我们计划开发一个博士后奖学金培训计划，并将提供一个特殊的培训环境。我们的培训计划通过以下方面的相互作用得到加强：对神经系统传染病的跨学科方法;关注服务不足的人群，包括资源有限的国家;强调以患者为导向或实验室研究设计的科学和方法论严谨性;在国内和国际上进行道德健全，以社区为基础的研究的各种机会;以及在多个不同领域的广泛临床和研究专业知识。我们要求在培训的第一年支持2个博士后职位，此后增加到3个博士后职位。学员将继续神经系统感染培训的三个轨道之一，包括实验室研究，临床和转化研究或国际研究。博士后培训将侧重于指导研究，无论是在以病人为导向的或实验室领域，与指导研究分析，论文和赠款写作的指导教师顾问。我们的方法来培训科学家在神经传染病的职业生涯将强调灵活性和基于核心课程和临床研究生培训计划的可用性定制的培训计划。培训教师有多年的经验，成功的博士后培训和指导神经学家和其他临床科学家。我们的培训计划的成功将通过研究经验以及广泛的研究来衡量，我们预计该计划的学员将成功地竞争科斯或K23资金。这些赠款资金将为我们的神经传染病研究培训计划提供核心的必要支持。这项建议将满足培养下一代临床科学家的重要和关键需求 相关性：该提案将为神经传染病的临床科学家创建一个新的培训计划。神经感染性疾病是发病率、死亡率和住院时间延长的重要原因。然而，许多这些疾病的病因学和病理生理学知之甚少，也没有有效的治疗方法。该计划将是该国第一个致力于培养下一代专门研究这些疾病的研究人员的计划。

DESCRIPTION (provided by applicant): This new competing application requests support for establishment of an institutional NRSA in Neurological infectious Diseases at Johns Hopkins University. Neurological infections are a major cause of morbidity and mortality yet currently there are no other training programs in the country focused on neurological infections. We plan to develop a post-doctoral fellowship training program and will provide an exceptional training environment. Our training program is strengthened by the interaction of the following: an interdisciplinary approach to neurological infectious disease; focus on underserved populations, including those in resource limited countries; emphasis on scientific and methodological rigor in the design of patient-oriented or laboratory research; diverse opportunities to conduct ethically sound, community-based research both domestically and internationally; and broad clinical and research expertise in several different areas. We are requesting support for 2 post-doctoral slots during the first year of training, increasing thereafter to 3 post-doctoral slots. The trainees will pursue one of three tracks of training in neurological infections which includes laboratory based research, clinical and translational research or international research. Post-doctoral training will focus on mentored research, either in patient-oriented or laboratory areas, with a faculty advisor guiding research analysis, paper and grant writing. Our approach to training scientists for careers in Neurological Infectious Diseases will emphasize flexibility and a customized training program based on a core curriculum and the availability of the Graduate Training Program in Clinical Investigation. Training faculty has many years of experience with successful post-doctoral training and mentoring neurologists and other clinician-scientists. The success of our training program will be measured by research experiences, plus a wide array of studies and we anticipate that trainees from this program will compete successfully for KOS or K23 funding. These grant funds will provide a core of essential support for our Neurological Infectious Disease Research Training Program. This proposal will fulfill an important and critical need for training a future generation of clinician scientists RELEVANCE: The proposal will create a new training program for clinician scientists In neuro-infectious diseases. Neuroinfectlous diseases are a significant cause of morbidity, mortality and prolonged hospitalization. Yet, the eitiology and pathophysiology of many of these disaeses is poorly understood and no treatemtment is available. This program will be the first of its kind in the country devoted to training the next generation of researchers who specialize in these diseases.