Midcareer Investigator Award in Patient-Oriented Research

描述（由申请人提供）：这是一份由威尔康奈尔医学院的Mark Lachs医学博士和公共卫生硕士续签的K24老年患者导向研究指导奖的申请。该计划的直接目标是(1)将候选人在第一个周期中与Linda Fried博士合作创建的成功的指导计划扩展到哥伦比亚大学的任何指导者指导的老龄化研究领域的受训者（当地计划），以及(2)为老年人虐待领域的初级调查员创建一个国家指导计划（国家计划）。这两项倡议都源于第一个周期中确定的阻碍两个特定学员群体职业发展的障碍。就拟议的地方项目而言，哥伦比亚大学世界知名的老龄化研究活动尚未对其老年医学部门产生严重影响。就拟议的国家项目而言，在虐待老人领域缺乏训练有素的调查人员，他们可以指导下一代研究人员，这是一个可怕的问题；Lachs博士是NIH历史上唯一一位在该领域持有RO1的医师科学家，这是K24机制的要求。在第一个K24周期的过程中，希望获得指导的两种类型的学员都会定期与候选人联系；这次更新使这一过程正规化，同时继续为原始计划创造的潜在学员提供稳定的服务。第一个周期的显著成就包括：指导24名各级学员，他们与PI共同撰写了多篇出版物，并获得了许多联邦和基金会的资助；更新了父母RO1——NIA历史上最大的老年人虐待资助，用于研究养老院的住院老人虐待（RREM）；为PI获得了另外三笔主要资助，作为学员的资源；获得或续签康奈尔大学的几个主要中心拨款（PI协助），这些拨款有试点项目和其他资源，可以帮助全国和当地的学员。其中包括NIA资助的皇家中心（由前学员卡里·里德博士领导），NIMH老年抑郁症中心的更新（由长期合作伙伴乔治·亚历克斯波洛斯博士领导），以及CTSC（由同事部门主任朱丽安·Imperato-McGinley博士领导）。在最初的一年里，我们提出了三个试点项目，涉及两个项目的不同层次的学生：(1)哥伦比亚大学老年病专家Tien Dam博士（地方项目）对送餐者补充维生素D的研究，(2)罗切斯特大学老年精神病学家EJ Santos（国家项目）对RREM中精神疾病合并症的研究，(3)康奈尔大学ED住院医生Anthony Rosen（地方项目）对辅助生活设施中RREM的研究。PI已经为每个项目提供了数据集和/或研究资源，这标志着后续指导将如何构建。申请的另一个优势是拉克斯博士的同事珍妮·特蕾西博士和她在希伯来老人之家的研究小组的共同指导。作为一名心理测量学家和统计学家，Teresi博士是他目前所有项目的合作研究者，并指导了200多人进行老龄化研究。K24项目的长期目标是：(1)更充分地整合康奈尔大学和哥伦比亚大学的以患者为导向的老龄化研究，从而激励更多的学员选择老龄化研究领域的职业；(2)建立一支自我维持的研究队伍，开展以患者为导向的老年人虐待研究。国家和地方项目的首要和长期目标是，它们最终能够自我维持，独立于候选人，因为学员承担导师的角色。

DESCRIPTION (provided by applicant): This is an application for renewal of a K24 mentoring award in patient oriented research in aging from Mark Lachs MD MPH of the Weill Cornell Medical College. The immediate objectives of the program are (1) to extend the candidate's successful program of mentorship created in the first cycle to trainees at Columbia University in collaboration with Dr. Linda Fried in any mentee-directed area of aging research (the local program), and (2) to create a national mentorship program for junior investigators in the field of elder abuse (the national program). Both initiatives derive from barriers identified in the first cycle which hamper career development of two specific mentee constituencies. In the case of the proposed local program, the world renowned aging research activities of Columbia University have not yet highly impacted its Division of Geriatric Medicine. In the case of the proposed national program, dearth of highly trained investigators in the field of elder abuse who can mentor the next generation of researchers is a dire concern; Dr. Lachs is the only physician-scientist in the history of NIH to hold an RO1 in the field, a requirement of the K24 mechanism. Over the course of the first K24 cycle, the candidate was contacted regularly by trainees of both types desirous of mentorship; this renewal formalizes that process while continuing to serve the steady pool of potential mentees created by the original program. Notable achievements in the first cycle include: the mentorship of 24 trainees at all levels who coauthored multiple publications with the PI and received many federal and foundation grants, renewal of the parent RO1 - the largest elder abuse grant in the history of NIA to study resident to resident elder mistreatment (RREM) in nursing homes, the acquisition of three other major grants to the PI which will serve as a resource for mentees, and the acquisition or renewal of several major center grants at Cornell (with which the PI assisted) that have pilot programs and other resources than can assist mentees nationally and locally. These include an NIA funded Roybal Center (led by former mentee Dr. Cary Reid), renewal of an NIMH Geriatric Depression Center (led by longstanding collaborator Dr. George Alexopolous), and a CTSC (led by fellow Division Chief Dr. Julianne Imperato-McGinley). Three pilot projects involving mentees at different levels in both arms of the program are proposed for the initial year: (1) A study of Vitamin D supplementation in meals on wheels recipients by Columbia geriatrician Dr. Tien Dam (local program), (2) A study of psychiatric co-morbidity in RREM by University of Rochester Geriatric Psychiatrist EJ Santos (national program), and (3) a study of RREM in assisted living facilities by Cornell ED Resident Anthony Rosen (local program). The PI has made data sets and/or research resources available for each project, emblematic how subsequent mentoring will be structured. An additional strength of the application is co-mentorship from Dr. Lachs' colleague Dr. Jeanne Teresi and her research group at the Hebrew Home for the Aged. A psychometrician and statistician, Dr. Teresi is a collaborating investigator all his current projects, and has mentored over 200 individuals in aging research. The Long Term Objectives of the K24 program are (1) to more fully integrate patient oriented research in aging at Cornell and Columbia, thereby inciting more trainees to select careers in aging research, and (2) to create a self-sustaining cadre of researchers who conduct patient oriented research in elder abuse. The overarching and longest term objective for both the national and local programs is that they ultimately be self-sustaining and independent of the candidate, as mentees take on mentor roles.