Anti-counterfeit edible integral lens array for pharmaceuticals

项目摘要/摘要 由于药品价格昂贵，该病的发病率越来越高。 已经进入市场的假冒药品。这些假冒产品代表着 这给公众带来了重大危险，因为它使他们无法安全地获得所需的药物。当前 打击造假者的技术包括特殊的包装标签，确保批次和来源 毒品的问题。然而，这些包装并不能防止用假冒产品重新填充空瓶子 剂型。作为一项加强防止假冒的措施，拟议的努力将 演示“每片”3-D序列号标记过程的可扩展可制造性。 在第一阶段，我们演示了在商业上可获得的可食用墨水上沉积的紫外线写入 食用纸通过一体式可食用透镜阵列。此外，我们还展示了 空间光调制器，用于投影简单的点阵图案，传递图像，或根据需要 制作详细的全息投影。这种灵活性，以及 透镜阵列，提供编码信息的复杂程度的选择矩阵 这本身就与制造的困难程度有关，当然还有相关的成本 保护药品的安全。这将为该行业提供规模不断扩大的能力 在信息编码方面。从简单的模式到支持可追溯性的一切 常见的货架和久负盛名的药品以更复杂的编码信息来 保护更有可能成为假冒目标的高端药品 会是有空的。在第二阶段，我们将研究在可制造性和成本方面的权衡 开发一种可变的“定制”制造流程，包括从简单到简单的一切 使用透镜阵列标记到3D成像，甚至构建全全息图。

Project Summary/Abstract Owing to the high cost of pharmaceuticals, there has become an ever increasing incidence of drug counterfeiting which has entered the market place. These counterfeit products represent significant danger to the public as it denies them safe access to needed medications. Current technologies to thwart counterfeiters include special packaging labels, ensuring lot and source of drug. However, these packages do not prevent refilling of empty bottles with counterfeit dosage forms. As an increased measure to prevent counterfeiting, the proposed effort will demonstrate the scalable manufacturability of a "per tablet" 3-D serial number labeling process. In Phase I we demonstrated UV writing to onto commercially available edible ink deposited on edible paper through an integral edible lens array. In addition, we demonstrated the ability of the spatial light modulator to project simple dot-matrix patterns, relay an image, or if required, to produce a detailed holographic projection. This flexibility, along with the added capability of the lens arrays, provides a matrix of choices for the level of complexity of encoded information which itself relates to the degree of difficulty in manufacturing and of course the associated cost of protecting the pharmaceutical. This will provide the industry with a sliding scale of capabilities in terms of information encoding. Everything from simple patterns to enable traceability of common over the shelf and well-established drugs to more complex encoded information to protect high end pharmaceuticals that are more likely to be the target of counterfeiting attempts would be available. During Phase II we will study the trade-offs in manufacturability and cost to develop a variable "custom" manufacturing process that would including everything from simple marking to 3-D imaging using lens arrays or even constructing full holograms.