Investigating the roles of the wnt and notch signalling systems in colon cancer crypt biology
Investigating the roles of the wnt and notch signalling systems in colon cancer crypt biology
批准号:
nhmrc : 1029628
负责人:
Prof Antony Burgess
金额:
$40.3万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31
中文摘要
结肠癌的发生是由于一种肿瘤抑制基因的突变。这些突变改变了癌细胞的生长和位置信号。该项目旨在建立一个正常结肠细胞调控过程的计算机模型,以发现突变导致癌症的原因,并找到干扰结肠癌细胞生长的合理药物靶点。
英文摘要
Colon cancer occurs because of mutations to a tumour suppressor gene. These mutations alter the growth and positional signals for the cancer cells. This project aims to produce a computer model of the regulatory processes in normal colonic cells, to discover why the mutations lead to cancer and to discover rational drug targets for interfering with the growth of colon cancer cells.
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会议论文
Wnt signalling in colon cancer
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批准号:nhmrc : 542531
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项目类别:NHMRC Project Grants
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资助金额:$36.72万
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财政年份:2009
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负责人:Prof Antony Burgess
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依托单位:
Analysis of signal transduction pathways induced by the EGF receptor
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批准号:nhmrc : 981138
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项目类别:NHMRC Project Grants
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资助金额:$10.98万
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财政年份:1998
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负责人:Prof Antony Burgess
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依托单位:
Functional analysis of the Apc protein using embryonic stem cells
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批准号:nhmrc : 981137
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项目类别:NHMRC Project Grants
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资助金额:$11.52万
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财政年份:1998
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负责人:Prof Antony Burgess
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依托单位:
海外基金