Robust person-centered longitudinal data analysis for clinical alcohol research

描述（申请人提供）：本申请提出在以人为中心的纵向统计模型中开发三个关键组件：（a）一项全面的模拟研究，旨在了解用于推导基于群体的轨迹的各种模型的细微差别，（B）一项交叉验证程序，旨在增强信心（在复制和一致性方面）这些模型用于对照临床试验和有效性试验时，以及（c）通过开发用户友好，免费提供的软件，带有图形用户界面。

DESCRIPTION (provided by applicant): This application proposes to develop three key components in person-centered longitudinal statistical models: (a) a comprehensive simulation study designed to understand the nuanced performance of a wide range of models used to derive group based trajectories, (b) a cross-validation procedure designed to bolster the confidence (in terms of replication and consistency) of these models when employed in controlled, clinical trials and effectiveness trials, and (c) to promote dissemination of these advanced techniques by developing a user- friendly, freely available software with a graphical-user interface.