IMMUNOLOGIC/GENETIC MECHANICSMS IN RHEUMATIC DISEASES

描述（由申请人提供）：本研究培训计划的总体目标是提供与风湿性疾病相关的实验室或非实验室研究的广泛研究经验。该计划侧重于自身免疫和结缔组织疾病。正式的课程以及对疾病发病机制的跨学科强调为培训计划提供了一个结构。该计划旨在提供具有基础科学背景和临床培训的个人之间的交叉受精。博士前候选人（要求三个职位）和博士后研究员（要求两个职位）可以从不同的临床和基础科学教师中选择导师。开展临床研究的基础设施得到了大学GCRC和最近资助的CTSA的加强。系统性自身免疫性疾病（狼疮，干燥综合征，类风湿性关节炎）的程序是最大的GCRC用户。在过去的资助期间，通过招聘教师，加强了临床/转化研究的培训机会。培训教师的研究兴趣分为以下几类：1）骨髓细胞功能，2）淋巴细胞生物学，3）动物模型，4）免疫治疗，细胞因子，趋化因子，5）临床免疫学/生物标志物，6）干细胞生物学，7）自身免疫性疾病的遗传学/表观遗传学，和8）基因/细胞治疗。培训计划主要是指导性的，学员75%以上的时间用于独立研究活动，其余时间用于正式课程和会议。课程根据学员的个人需要量身定制。该学院有着积极合作的良好记录。参与部门包括医学;儿科;病理学，免疫学和实验室医学;分子遗传学和微生物学;生物化学和分子生物学;流行病学和生物统计学;卫生政策和流行病学;口腔生物学;和口腔外科。在过去5年和10年期间完成该计划的学员在研究出版物和随后的职业发展方面取得了非常成功，11名完成培训的人员中有6名在学术界和3名在工业界担任职务。

DESCRIPTION (provided by applicant): The overall objective of this research training program is to provide a broad investigational experience in laboratory or non-laboratory research related to rheumatic diseases. The Program focuses on autoimmunity and the connective tissue diseases. Formal curricula as well as an interdisciplinary emphasis on disease pathogenesis provide a structure for the training program. The program is designed to provide cross- fertilization between individuals with a basic science background and those with clinical training. Pre- doctoral candidates (three positions requested) and postdoctoral fellows (two positions requested) may select mentors from a diverse clinical and basic science faculty. The infrastructure for carrying out clinical research is enhanced by the University's GCRC and the recently funded CTSA. The program in systemic autoimmune disease (lupus, Sjogren's syndrome, rheumatoid arthritis) is the largest GCRC user. Training opportunities in clinical/translational research were strengthened through faculty recruitment over the past funding period. Research interests of the training faculty fall into the following categories: 1) Myeloid cell function, 2) lymphocyte biology, 3) animal models, 4) immunotherapy, cytokines, chemokines, 5) clinical immunology/biomarkers, 6) stem cell biology, 7) genetics/epigenetics of autoimmune disease, and 8) gene/cell therapy. The training program is largely preceptorial, with more than 75% of the trainee's time devoted to independent research activities and the rest spent in formal courses and conferences. The curriculum is tailored to trainees' individual needs. The Faculty has a strong track record of active collaboration. Participating departments are Medicine; Pediatrics; Pathology, Immunology & Laboratory Medicine; Molecular Genetics & Microbiology; Biochemistry & Molecular Biology; Epidemiology & Biostatistics; Health Policy & Epidemiology; Oral Biology; and Oral Surgery. Trainees completing the program over the past 5 and 10-year periods have been highly successful in terms of research publications and their subsequent career development, and 6 of 11 individuals who have completed their training have assumed positions in academia and 3 in industry.