Investigating the Transcriptional Circuitry of Normal Human Haematopoietic and Leukaemic Cells

尽管支持性治疗有所改善，但超过一半的急性髓性白血病（AML）患者死于与疾病或治疗相关的并发症。为了改善治疗效果，我们需要了解白血病细胞如何自我更新，以及这与正常造血干细胞有何不同。我们的建议旨在通过使用计算和实验方法来识别和验证白血病细胞比正常血细胞更依赖的因素。

Despite improvements in supportive care, more than half the patients diagnosed with acute myeloid leukaemia (AML) succumb to complications associated with the disease or its treatment. To improve treatment outcomes, we need to understand how leukaemic cells self-renew and how this differs from normal blood stem cells. Our proposal aims to do this by using computational and experimental methods to identify and validate factors to which leukaemic cells are more dependent than normal blood cells.