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testing the effect of a DPP-4 inhibitor on immune function

testing the effect of a DPP-4 inhibitor on immune function
测试 DPP-4 抑制剂对免疫功能的影响
批准号：
8741575
负责人：
Kristin Tarbell
金额：
$29.72万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8741575
关键词：
AftercareAutoimmune DiabetesAutoimmune ProcessAutoimmunityBeta CellBlood GlucoseBlood specimenCell physiologyCleaved cellClinical ProtocolsClinical TrialsDataDiabetes MellitusDipeptidyl-Peptidase IVDiseaseDouble-Blind MethodEnzymesFlow CytometryGene ExpressionHalf-LifeHyperglycemiaImmuneImmune responseImmune systemIndividualInfectionInflammationInsulinInsulin-Dependent Diabetes MellitusLeukocyte TraffickingLeukocytesLymphocyte SubsetMeasuresMinorMusNon-Insulin-Dependent Diabetes MellitusPancreasPatientsPlacebosPlasmaProductionProteinsPublicationsRandomizedRegulatory T-LymphocyteStructure of beta Cell of isletTestingToxic effectTransforming Growth Factor betaWhole Bloodchemokineclinically relevantcytokineglucagon-like peptidehealthy volunteerhuman TGFB1 proteinimmune functionimprovedimproved functioninginhibitor/antagonistinsulin dependent diabetes mellitus onsetkillingsprimary outcometime interval

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中文摘要
翻译
在过去的一年里，我们完成了对临床方案结果的计划分析，评估了DPP-4特异性抑制剂(Sitagliptin/Januvia)对健康个体免疫功能的影响。我们的分析表明，西格列汀不会显著改变我们测量的大多数免疫读数，包括血浆转化生长因子-β和其他细胞因子的水平，以及PBMC上的流式细胞术。收集的流式细胞仪数据包括Treg分析和淋巴细胞亚群上CD26的表达。我们确实观察到西格列汀治疗后早期CD26表达的微小但显著的变化，但这些变化不是持续的，因此不太可能与临床相关。这项研究已经被接受出版。
英文摘要
In the past year, we have completed planned analysis of results from the clinical protocol, Assessment of the Effects of A DPP-4-Specific Inhibitor (Sitagliptin/Januvia) on Immune Function in Healthy Individuals. Our analysis has indicated that sitagliptin does not significantly alter most of the immune readouts we measured, including levels of plasma TGF-beta and other cytokines, and flow cytometry on PBMCs. Flow cytometry data collected include Treg analysis and expression of CD26 on lymphocyte subsets. We did observe small but significant changes in CD26 expression early after sitagliptin treatment, but these changes were not sustained, and therefore are not likely to be clinically relevant. This study has been accepted for publication.
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testing the effect of a DPP-4 inhibitor on immune function
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