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Role of brown adipose tissue (BAT) in energy balance

Role of brown adipose tissue (BAT) in energy balance
棕色脂肪组织(BAT)在能量平衡中的作用
批准号:
8741604
负责人:
MARC L REITMAN
金额:
$28.01万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
虽然蝙蝠在维持体温方面的作用是明确的,但蝙蝠对体重调节的作用还没有被很好地理解。Rothwell和Stock(《自然》,1979)表明,以高脂肪饮食过量喂养啮齿动物会刺激蝙蝠,这表明蝙蝠在限制体重增加方面发挥了作用。然而,BAT具有这一功能的想法远未被普遍接受。 实验现在正在设计中,其他实验正在进行中,用小鼠来检验BAT对调节体重(和肥胖)和胰岛素抵抗的作用。
英文摘要
While the role of BAT in maintaining body temperature is unambiguous, BATs contribution to body weight regulation is not well understood. Rothwell and Stock (Nature, 1979) showed that overfeeding rodents a high fat diet stimulated BAT, suggesting a role for BAT in limiting weight gain. However, the idea that BAT has this function is far from universally accepted. Experiments are now being designed and others underway using mice to examine the contribution of BAT to regulation of body weight (and adiposity) and insulin resistance.
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Studies in Youths & Young Adults with Obesity & T2DM (07-DK-0115, 10-DK-0163)
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