NIAMS Multidisciplinary Clinical Research Center

描述（由申请人提供）：响应2012年医学研究所报告的紧急行动呼吁。慢性病患者生活良好：呼吁采取公共卫生行动， 在2010年国家骨关节炎公共卫生议程（NPHAOA）中，该申请提出了在北卡罗来纳州大学（University of North Carolina）的Thurston关节炎研究中心（TARC）的新的多学科临床研究中心（MCRC），题为减轻OA的公共卫生影响。建议的MCRC将多个单位和新的OA研究人员聚集在一起，形成新的合作关系，长期目标是：1）了解与OA发展和进展及其导致的残疾相关的病因因素; 2）确定最佳做法，为社区采纳关键公共卫生建议提供信息，以防止这些结果的发生和发展，和3）通过作为创新，培训和合作的中心，改变了OA研究在ESTA校园的面貌。NPHAOA建议解决关节损伤预防，增加体力活动，体重控制和关节炎自我管理教育，以减缓这一迫在眉睫的公共卫生危机。该MCRC将以这些主题为重点，并利用2项独特的膝关节损伤研究：1）约翰斯顿县OA项目，一项在NC的非裔美国人和白色男性和女性中进行的为期20年以上的OA和残疾前瞻性队列研究，以及2）JUMP-ACL，一项研究男性和女性军事学员膝关节损伤的独特队列研究，其中可获得损伤前生物力学数据和生物标本。项目#1解决了合作伙伴支持在开始和维持增加的身体活动中的作用背后的基本机制。项目#2检查了生物力学和生物标志物在预测膝关节损伤和损伤介导的OA发展中的关系。方法学核心是核心，将支持2个拟议项目和多个其他现存项目相关的使命的NIAMS，并将促进新的研究和提供培训的研究方法和指导下一代关节炎研究人员。中心将由一个行政核心、一个执行委员会以及内部和外部咨询委员会提供支助。通过将我们现有的调查人员与体育活动方面的新专业知识结合起来， 这个充满活力的中心将通过其在测量、生物力学和生物标志物以及新培训的年轻研究人员方面的经验，推进公共卫生OA议程，并为实施未来的干预措施以治疗和预防OA及其后果奠定基础。

DESCRIPTION (provided by applicant): Responding to an urgent call to action from the 2012 Institute of Medicine report. Living Well with Chronic Illness: A call for public health action and the 2010 National Public Health Agenda for Osteoarthritis (NPHAOA), this application proposes a new Multidisciplinary Clinical Research Center (MCRC) at the Thurston Arthritis Research Center (TARC) at the University of North Carolina (UNC), entitled Mitigating The Public Health Impact of OA. The proposed MCRC draws together multiple units and investigators new to OA research into novel collaborative relationships with the long-term goals of: 1) understanding the etiologic factors associated with development and progression of OA and Its resultant disability; 2) Identifying best practices to Inform adoption of critical public health recommendations in communities to prevent the occurrence and progression of these outcomes, and 3) transforming the face of OA research on the UNC campus by serving as a hub for Innovation, training, and collaboration. The NPHAOA recommends addressing joint injury prevention, increased physical activity, weight control, and arthritis self-management education to slow this looming public health crisis. This MCRC will use these themes as its focus and leverages 2 distinctive UNC studies: 1) the Johnston County OA Project, a 20+ year prospective cohort of OA and disability in African American and White men and women in NC, and 2) JUMP-ACL, a unique cohort studying knee injury in men and women military cadets in whom pre-injury biomechanics data and biological specimens are available. Project #1 addresses basic mechanisms behind the role of partner support in the initiation and maintenance of increased physical activity in insufficienty active people with OA. Project #2 examines the relationship between biomechanics and biomarkers in predicting knee injury and development of injury-mediated OA. The Methodology Core is central and will support the 2 proposed projects and multiple other extant projects relevant to the mission of NIAMS and will foster new research and provide training in research methodology and mentoring to the next generation of arthritis researchers. An Administrative Core with an Executive Committee and Internal and External Advisory Boards will support the Center. By bringing together our established investigators with new expertise in physical activity measurement, biomechanics, and biomarkers, and newly trained young investigators, this vibrant center will advance the public health OA agenda and lay the foundation for implementing future interventions to treat and prevent OA and its consequences.