Software for improved accuracy and rapid tracking of kinematics from dynamic Xray

描述（由申请人提供）：矫形障碍是美国残疾的主要原因，关节炎和/或脊柱问题对超过20%的成年人的生活质量产生不利影响。随着人口老龄化，骨科疾病的残疾率一直在稳步上升。虽然诊断成像（包括CT，MRI和超声）的进步大大提高了我们检测肌肉骨骼组织结构变化的能力，但它们通常对关节功能的揭示很少。有证据表明，异常的机械关节功能显着有助于许多类型的关节疾病的发展和进展。因此，临床上需要广泛的 使用技术，可以识别关节功能的细微异常，如果不治疗，可能会损害长期的关节健康。第一阶段SBIR项目的具体目标是通过整合匹兹堡大学Tashman博士实验室的双平面放射成像专业知识，扩展C-Motion的骨骼姿态（位置和方向）估计能力。动态立体X射线是目前唯一可以在各种功能运动中实现亚毫米精度的技术。然而，迄今为止，DSX提供用于诊断细微运动障碍和识别风险关节的独特且强大的工具的潜在承诺尚未实现为临床工具，AD仍然是未充分使用的临床研究工具。该项目的成功完成为开发一种全新的定量放射摄影方法奠定了基础，该方法将把一种有限使用的研究工具转变为一种强大的临床设备，用于动态评估肌肉骨骼功能。正如电影血管造影术彻底改变了心血管疾病的诊断和治疗一样，动态肌肉骨骼成像的广泛应用可以显着改善各种骨科疾病的治疗。

DESCRIPTION (provided by applicant): Orthopaedic disorders are a leading cause of disability in the U.S., with arthritis and/or spine problems adversely affecting quality of life fo more than 20% of adults. With an aging population, the rate of disability from orthopaedic disorders has been increasing steadily. While advances in diagnostic imaging (including CT, MRI and ultrasound) have greatly improved our ability to detect structural changes in musculoskeletal tissues, they typically reveal little about joint function. There is evidence that abnormal mechanical joint function contributes significantly to the development and progression of many types of joint disease. There is, therefore, a significant clinical need for the widespread use of technologies that can identify subtle abnormalities in joint function that, if left untreate, can compromise long-term joint health. The specific goal of this Phase I SBIR project is to extend C-Motion's capabilities for bone pose (position and orientation) estimation by incorporating the bi-planar radiography imaging expertise of Dr. Tashman's laboratory at the University of Pittsburgh. Dynamic Stereo X-ray is the only currently available technology that can achieve sub-mm accuracy during a wide variety of functional movements. To date, however, the potential promise of DSX to provide a unique and powerful tool for diagnosing subtle motion disorders and identifying at-risk joints has yet to be realized as a clinical tool, ad is still an under-used clinical research tool. The successful completion of this project sets the stage for the development of a fundamentally novel approach to quantitative radiography that would turn a limited-use research tool into a powerful clinical device for dynamic assessment of musculoskeletal function. Just as cine-angiography has revolutionized diagnosis and treatment of cardiovascular disorders, widespread availability of dynamic musculoskeletal imaging could significantly improve treatment for a wide variety of orthopaedic disorders.