Stroke Investigative Research & Educational Network (SIREN)

在此输入文本，它是您的应用程序的新摘要信息。此部分必须为no 超过30行的文本。 尽管中风是一种离散的表型，但它是几种复杂和 由各种遗传和环境因素促成的相互作用的生物过程，从而 使对其潜在机制的现成分析成为一项挑战。然而，关于 成功的量身定做的预防战略，以限制巨大的个人和社会负担 撒哈拉以南非洲的中风(SSA)取决于对易感风险的更好理解 该地区的中风因素，不一定与中风风险因素的性质相匹配 在其他大洲的其他人中被描述。事实上，中风的潜在风险因素在 到目前为止，SSA还没有得到全面的表征，目前还缺乏 SSA在基因组学和环境研究方面的专业知识、经验和基础设施，以发起 并继续进行这样的调查。 我们寻求建立中风调查研究和教育网络(SIREN)作为 SSA和美国调查人员的多学科合作研究网络 共同致力于探索促进更好地理解基因和 非洲血统人群中风的环境危险因素。警报器将评估唯一的 SSA中中风的贡献者，并将这些发现与非裔美国人队列中的研究结果进行比较 中风幸存者，所有这些都同时在表型组学、生物库、 基因组学、生物统计学和生物信息学为未来卒中和其他疾病的高水平研究提供了基础 SSA中的血管疾病实体。 SIREN由三个相互交织的黑人中风系统性调查(SIBS)组成 旨在对中风进行全面调查的项目：SIBS-表现学、SIBS-基因组学和 SIB-生物信息学。这些项目将在三个国家的八个地点实施(尼日利亚， 加纳和南非)，并将利用以前的经验和正在进行的合作，包括 之前参与了一项全球中风流行病学研究，并参与了目前的两项NIH- 资助了基于SSA的研究。来自美国知名内容专家的意见，在那里，社会 通过正确识别危险因素和预防措施，成功地减轻了中风的负担 通过系统化的网络，落实相应的预防策略 活动。 1 中风调查研究和教育网络(SIREN)

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Although stroke is a discrete phenotype, it is the clinical culmination of several complex and interacting biological processes, precipitated by various genetic and environmental factors, thereby making ready analyses of its underlying mechanisms a challenge. However, the formulation of successful tailor-made prevention strategies for limiting the immense personal and societal burden of stroke in Sub-Saharan Africa (SSA) is contingent on a better understanding of the predisposing risk factors for stroke in the region, which may not necessarily match the nature of stroke risk factors described among other people on other continents. Indeed, the underlying risk factors for stroke in SSA have hitherto not been comprehensively characterized, and currently there is a paucity of expertise, experience, and infrastructure in genomics and environmental research in SSA, to initiate and sustain such investigation. We seek to establish the Stroke Investigative Research and Education Network (SIREN) as a multidisciplinary collaborative research network of investigators in SSA and the United States collectively focused on exploring ways to promote a better understanding of the genetic and environmental risk factors for stroke among people of African ancestry. SIREN will evaluate unique contributors to stroke in SSA and compare these findings with those in a cohort of African American stroke survivors, all while simultaneously building sustainable capacities in phenomics, biobanking, genomics, biostatistics and bioinformatics for future high-level investigation of stroke and other vascular disease entities in SSA. SIREN is comprised of three interwoven Systematic Investigation of Blacks with Stroke (SIBS) projects geared at a comprehensive investigation of stroke: SIBS-Phenomics, SIBS-Genomics and SIBS-Bioinformatics. These projects will be implemented at eight sites in three countries (Nigeria, Ghana, and South Africa), and will leverage prior experience and ongoing collaborations including previous participation in a global stroke epidemiological study, and involvement in two current NIH- funded studies based in SSA. Input from renowned content experts in United States, where the societal burden of stroke has been successfully reduced through proper identification of risk factors and implementation of corresponding preventive strategies will be obtained through systematic network activities. 1 Stroke Investigative Research and Education Network (SIREN)