Child Health Career Development Program at UCSF

描述（由申请人提供）：本修订提案是为了响应RFA-HD-13-011，儿童健康研究职业发展奖（CHRCDA）计划，通过CHRCDA机制向年轻的儿科研究者提供K12奖项。申请要求资源，以支持每年四名儿科医生谁持有MD或MD/博士学位，并已完成奖学金培训的临床专科。该计划的基本原理是基于有据可查的和迫切需要支持儿科医生的指导职业发展，使他们成为完全独立和富有成效的基础科学研究人员，以及UCSF拥有培养下一代儿科科学领导者的愿景，经验和基础设施。我们的目标是（1）提供一个结构化的计划，培训学术儿科医生，（2）促进职业发展和促进初级教师的保留，（3）暴露有前途的早期职业儿科医生的知识丰富的UCSF研究和（4）促进学术儿科学的多样性。该计划培训的学者将带来最先进的方法来诊断，治疗和预防儿童健康问题以及儿童发病的成人疾病。该计划的设计涉及利用世界一流的基础实验室科学家的专业知识，他们将担任跨学科培训的导师。基础科学培训计划围绕七个科学核心：癌症，心肺医学，发育生物学，遗传学，免疫学，神经生物学和干细胞生物学。每个核心都有一个主任，指定的教师，和一个特定的教学课程。学者，与他们的导师和核心主任一起，还将参加一个额外的学科特定的课程工作计划，这取决于申请人的先前经验和培训以及受训者研究的科学主题，这些主题通常可能在不同的核心之间重叠。我们相信，儿科在UCSF的部门有远见，经验和基础设施，以培养学术儿科的下一代领导者。在这个应用程序中，我们提供的证据表明，该部门与更广泛的UCSF研究界一起，为年轻的儿科医生提供了一个特殊的环境，他们将通过CHRCDA机制获得基础科学研究人员的成功职业生涯的支持。例如，有超过1,000个研究实验室和2,200多个活跃的研究项目在UCSF，教师目前包括4名诺贝尔奖获得者，41名国家科学院成员，61名美国艺术与科学院成员，72名医学研究所成员，16名霍华德休斯医学研究所的研究员。该计划是对儿童健康未来的投资，因为 我们将培训的一组研究人员将利用先进的研究战略来解决紧迫的问题（例如，哮喘、癌症、传染病、宿主防御缺陷、糖尿病、肥胖以及心脏、大脑和其他器官的发育畸形），这将导致新的治疗方法来改善儿童健康结果。

DESCRIPTION (provided by applicant): This revised proposal is submitted in response to RFA-HD-13-011, Child Health Research Career Development Award (CHRCDA) Program to provide K12 awards through the CHRCDA mechanism to young pediatric investigators. The application requests resources to support four pediatricians each year who hold MD or MD/PhD degrees and have completed scholarship training in a clinical subspecialty. The rationale for the program is based on the well-documented and urgent need to support mentored career development for pediatricians to enable them to become fully independent and productive basic science researchers, and the fact that UCSF has the vision, experience and infrastructure to train the next generation of leaders in pediatric science. Our aims are to (1) offer a structured program for training academic pediatricians, (2) foster career development and promote retention of junior faculty, (3) expose promising early career pediatricians to the intellectual richness of UCSF research and (4) promote diversity in academic pediatrics. The scholars trained by this program will bring state-of-the-art approaches to bear on diagnosis, treatment and prevention of health problems in children as well as childhood onset of adult illness. The design of this program involves harnessing the expertise of world-class basic laboratory scientists who will serve as mentors for interdisciplinary training. The basic science training program is focused around seven scientific cores: cancer, cardiopulmonary medicine, developmental biology, genetics, immunology, neurobiology, and stem cell biology. Each core has a Director, designated faculty, and a specific didactic curriculum. The scholars, in conjunction with their mentor and Core Director, will also participate in a program of additional discipline-specific course work dependent on both the prior experience and training of the applicant and the scientific theme of the trainee's research, which may often overlap amongst different cores. We believe that the Department of Pediatrics at UCSF has the vision, experience, and infrastructure to train the next generation of leaders in academic pediatrics. In this application, we provide evidence that the Department together with the broader UCSF research community comprise an exceptional environment for preparing young pediatricians who will receive support through the CHRCDA mechanism for successful careers as basic science researchers. For example, there are over 1,000 research laboratories and over 2,200 active research projects at UCSF, and the faculty currently includes 4 Nobel laureates, 41 National Academy of Sciences members, 61 American Academy of Arts and Sciences members, 72 Institute of Medicine members, and 16 Investigators of the Howard Hughes Medical Institute. This program is an investment in the future of children's health, as the diverse group of researchers we will train will harness advanced research strategies to address urgent problems (e.g., asthma, cancer, infectious diseases, host defense defects, diabetes, obesity, and developmental malformations of the heart, brain, and other organs), that will result in new treatments to improve child health outcomes.