Central nervous system mechanisms of burning mouth syndrome

描述(由申请人提供)：灼口综合征(BMS)是一种口腔面部慢性疼痛障碍，影响大约2%-3%的人口。它与口腔粘膜的灼痛有关，尤其是舌头、颊粘膜、硬腭和嘴唇。这种疾病被认为是多因素影响的，包括小纤维病理、性激素水平、焦虑和压力。然而，这种疾病的中枢神经系统(CNS)机制在很大程度上仍不清楚。在我们正在进行的工作中，我们在一小部分患者中发现了BMS持续疼痛水平与脑功能障碍之间的联系。我们建议进行一项研究，该研究将考虑多种潜在的中枢神经系统异常，以解释BMS的症状。这项研究将包括40名BMS患者和20名健康对照。这些患者将包括20名BMS 1型患者和20名BMS 2型患者，BMS 1型患者描述随着时间的推移灼热疼痛增加，而BMS 2型患者与全天持续疼痛有关。参与者将接受为期两天的测试，包括脑电图仪(EEG)、功能磁共振成像和定量感觉测试(QST)。对于每一位BMS患者，我们将在上午和下午进行QST和EEG，以记录持续疼痛水平的影响(预计BMS 1型患者的疼痛水平差异最大)。如果我们的研究成功，它将提供一个长期计划的开始，以检查治疗的效果，并最终改进BMS的现有治疗方法。

DESCRIPTION (provided by applicant): Burning mouth syndrome (BMS) is an orofacial chronic pain disorder affecting approximately 2-3% of the population. It is associated with burning pain of the oral mucosa, particularly the tongue, buccal mucosa, hard palate, and lips. The disease is thought to have multifactorial influences, including of small fiber pathology, sex hormone levels, anxiety, and stress. However, the central nervous system (CNS) mechanisms of the disease remain largely unknown. In our ongoing work, we have found a link between ongoing pain levels in BMS and brain dysfunction in a small sample of patients. We propose a study that will take into account multiple potential CNS abnormalities that could explain the symptomatology of BMS. The study will include 40 patients with BMS and 20 healthy controls. The patients will include 20 with BMS type 1, in which patients describe increasing burning pain as the day progresses, and 20 with BMS type 2, which is associated with constant pain throughout the day. Participants will undergo testing for two days, which will include electroencephalograph (EEG), functional MRI, and quantitative sensory testing (QST). In each BMS patient, we will perform QST and EEG in the morning and in the afternoon to capture the effects of ongoing pain levels (which is expected to vary most in BMS type 1 patients). If our study is successful, it would provide the beginnings of a long-term program to examine the effects of treatment and ultimately improve available treatments for BMS.