Central nervous system mechanisms of burning mouth syndrome

描述（由申请人提供）：灼口综合征（BMS）是一种影响约2-3%人口的口面慢性疼痛疾病。它与口腔粘膜的烧灼痛有关，特别是舌、颊粘膜、硬腭和嘴唇。该疾病被认为具有多因素影响，包括小纤维病理、性激素水平、焦虑和压力。然而，该疾病的中枢神经系统（CNS）机制在很大程度上仍然未知。在我们正在进行的工作中，我们发现了BMS持续疼痛水平与小样本患者脑功能障碍之间的联系。我们提出了一项研究，将考虑到多种潜在的中枢神经系统异常，可以解释BMS的药理学。该研究将包括40名BMS患者和20名健康对照。患者将包括20名1型BMS患者，其中患者描述随着时间的推移，烧灼痛增加，20名2型BMS患者，这与全天持续疼痛有关。参与者将接受为期两天的测试，其中包括脑电图（EEG），功能性MRI和定量感觉测试（QST）。在每名BMS患者中，我们将在上午和下午进行QST和EEG，以捕获持续疼痛水平的影响（预计在BMS 1型患者中变化最大）。如果我们的研究成功，它将提供一个长期计划的开始，以检查治疗的效果，并最终改善BMS的可用治疗方法。

DESCRIPTION (provided by applicant): Burning mouth syndrome (BMS) is an orofacial chronic pain disorder affecting approximately 2-3% of the population. It is associated with burning pain of the oral mucosa, particularly the tongue, buccal mucosa, hard palate, and lips. The disease is thought to have multifactorial influences, including of small fiber pathology, sex hormone levels, anxiety, and stress. However, the central nervous system (CNS) mechanisms of the disease remain largely unknown. In our ongoing work, we have found a link between ongoing pain levels in BMS and brain dysfunction in a small sample of patients. We propose a study that will take into account multiple potential CNS abnormalities that could explain the symptomatology of BMS. The study will include 40 patients with BMS and 20 healthy controls. The patients will include 20 with BMS type 1, in which patients describe increasing burning pain as the day progresses, and 20 with BMS type 2, which is associated with constant pain throughout the day. Participants will undergo testing for two days, which will include electroencephalograph (EEG), functional MRI, and quantitative sensory testing (QST). In each BMS patient, we will perform QST and EEG in the morning and in the afternoon to capture the effects of ongoing pain levels (which is expected to vary most in BMS type 1 patients). If our study is successful, it would provide the beginnings of a long-term program to examine the effects of treatment and ultimately improve available treatments for BMS.