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Imaging Guided Surgery using Fluorescently Labeled Cetuximab

Imaging Guided Surgery using Fluorescently Labeled Cetuximab
使用荧光标记的西妥昔单抗进行影像引导手术
批准号：
8765574
负责人：
EBEN L. ROSENTHAL
金额：
$26.81万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-07-01 至 2016-06-30
来源：
https://reporter.nih.gov/project-details/8765574
关键词：
AntibodiesBedsBlindedCetuximabCharacteristicsClinicClinical TrialsDataData AnalysesDetectionDevelopmentDiagnosticDiseaseDoseEGFR Protein OverexpressionEpidermal Growth Factor ReceptorEpitheliumEquipmentExcisionExplosionFDA approvedFluorescenceFrozen SectionsFundingHead and Neck CancerHumanImageImage-Guided SurgeryImageryImaging DeviceInflammatoryInstitutional Review BoardsLabelMalignant NeoplasmsMeasuresMicroscopicModelingOperating RoomsOperative Surgical ProceduresOutcomePatient SchedulesPatientsPre-Clinical ModelPrimary NeoplasmProceduresRecruitment ActivityResectedSafetySamplingSensitivity and SpecificitySpecimenSurgeonSurvival RateSystemTechniquesTherapeuticTherapeutic AgentsTherapeutic UsesTimeTissuesTongue NeoplasmsToxic effectTranslationsTumor Tissuecancer surgerycancer typeimprovedin vivoinnovationintraoperative imagingintravenous administrationnonhuman primatenoveloncologyoptical imagingpre-clinicalpublic health relevancereceptor expressionstandard of caretumortumor specificitywound

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中文摘要
翻译
描述（由申请人提供）：来自我们实验室和其他实验室的证据已经证明了荧光标记抗体在测量显微疾病以指导手术干预临床前模型方面的潜力。我们提出新的数据证明了荧光标记抗EGFR抗体在非人灵长类动物中的安全性。我们提出在手术室现有影像学设备下，应用荧光标记西妥昔单抗检测亚临床肿瘤，指导头颈部肿瘤手术切除的临床试验。拟议的试验已于2013年9月获得IRB和IND的批准。
英文摘要
DESCRIPTION (provided by applicant): Evidence from our lab and others has demonstrated the potential of fluorescently labeled antibodies to measure microscopic disease to guide surgical intervention preclinical models. We present novel data demonstrating safety of the fluorescently labeled anti- EGFR antibody in non-human primates. We propose a clinical trial with fluorescently labeled cetuximab to detect subclinical cancer in the operating room existing imaging equipment to guide surgical resection of head and neck cancer. The proposed trial has received IRB and IND approval in September 2013.
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会议论文
American Head and Neck International Conference
Targeted Dual Modality Imaging for Detection and Removal of Head and Neck Cancer
Targeted Dual Modality Imaging for Detection and Removal of Head and Neck Cancer
Next Generation Sentinel Node Mapping
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