Chemical Biology of Infectious Diseases (CBID) Training Program

 描述(申请人提供)：抗菌素耐药性病原体数量的迅速增加和新的感染威胁的出现突显了在制药业基本上放弃这一研究和开发领域之际，对新的抗菌疗法的迫切需求。学术研究机构已经开始满足这一需求，但要想成功，需要训练有素的科学家将化学生物学技术应用于微生物发病机制的研究。在此，我们建议利用范德比尔特大学在化学生物学和微生物学方面的优势，建立传染病化学生物学培训计划(CBIDTP)，旨在为科学家应对抗微生物靶标识别和药物发现的挑战做好准备。来自医学院(病理学、微生物学和免疫学、生物化学和儿科)和文理学院(化学和生物科学)五个系的20名教员将担任该计划的导师。每年将选出三名博士前学生，在他们五年计划的第二年和第三年学习期间接受两年的支持。培训计划的亮点包括微生物发病机制和化学生物学的正式课程、专门培训的选修课、合作者实验室的“小型休假”研究机会、研究和专业发展研讨会、化学生物学系列互动研讨会、化学生物学年度研究研讨会、参加传染病病例会议和抗生素管理计划、在一家大型制药公司的创新实习经验，以及深入的实验室研究经验。研究项目将强调将化学生物学应用于微生物学研究的多学科方法，学生将得到至少两名CBID导师的建议。因此，学生将在一个核心学科上打下良好的基础，并在互补领域得到足够好的培训，使他们能够在跨学科环境中有效地工作。

 DESCRIPTION (provided by applicant): The rapidly increasing number of antibacterial-resistant pathogens and the emergence of new infectious threats underscore the desperate need for new antimicrobial therapeutics at a time when the pharmaceutical industry has largely abandoned this area of research and development. Academic research institutions have begun to meet this need, but success will require scientists who are trained to apply the techniques of chemical biology to the study of microbial pathogenesis. Herein, we propose to capitalize on Vanderbilt University's strengths in chemical biology and microbiology to establish a Chemical Biology of Infectious Diseases Training Program (CBIDTP) aimed at preparing scientists for the challenges of antimicrobial target identification and drug discovery. Twenty faculty preceptors from five departments in the School of Medicine (Pathology, Microbiology & Immunology, Biochemistry, and Pediatrics) and the College of Arts and Sciences (Chemistry and Biological Sciences) will serve as mentors for the Program. Three predoctoral students will be selected each year to receive two years of support during their second and third year of study in the five-year program. Highlights of the training program include formal coursework in both microbial pathogenesis and chemical biology, elective courses for specialized training, a "mini-sabbatical" research opportunity in a collaborator's laboratory, research and professional development workshops, an interactive seminar series in chemical biology, an annual research symposium in chemical biology, participation in the infectious disease case conference and antibiotic stewardship program, an innovative internship experience at a major pharmaceutical company, and an in-depth laboratory research experience. Research projects will emphasize a multi-disciplinary approach that applies chemical biology to the study of microbiology, and students will be advised by at least two CBID preceptors. As a result, students will be well-grounded in a core discipline and sufficiently well-trained in complementary fields to allow them to work effectively in an interdisciplinary environment.