K24 Clinical research in Antimicrobial Resistance and Hospital Epidemiology

描述（由申请人提供）：目前的提案是对先前资助的K24的竞争性更新。首席研究员安东尼·哈里斯博士是一名传染病医生和流行病学家。在他担任教师的14年里，他发表了125多篇手稿。在这些手稿中，他是50多部的第一或最后作者。这些手稿大多集中在以下研究领域：抗菌素耐药性、医院流行病学、感染控制以及抗菌素耐药性研究中的流行病学和统计方法。从他的指导到现在，他的学员已经发表了450多篇论文。101份出版物已成为指导者/导师出版物。33名学员中有18人目前正在从事学术医学事业。在K24的最初五年里，他成功完成了所有提出的目标，并指导了六名教师的职业发展奖项。在K24期间，他发表了超过46篇文章，其中44篇涉及学员。他目前的资助水平包括一份NIH R01，一份AHRQ R01，一份经常要求额外分包合同的CDC合同，一名NIH合同的联合研究员和两项行业资助的研究补助金。K24的更新对于他继续在抗生素耐药性，医疗保健相关感染和医院流行病学等新兴领域指导年轻研究人员并继续发展他的研究至关重要。他将学习额外的课程，以帮助他的研究进入集群随机试验、基因组流行病学、比较有效性研究以及微生物组和抗生素耐药性研究等领域。受保护的时间对哈里斯博士实现这些目标至关重要；如果没有K24的续期，他将不得不更多地参加传染病服务，并进行更多的医院流行病学和质量改进，以增加对其工资的报销。

DESCRIPTION (provided by applicant): The current proposal is a competitive renewal of a previously funded K24. The Principal Investigator, Dr. Anthony Harris, is an infectious disease physician and epidemiologist. During his fourteen years as faculty, he has had more than 125 manuscripts published. Among these manuscripts, he has been first or last author on more than 50. Most of these manuscripts have been focused in the following research areas: antimicrobial resistance, hospital epidemiology, infection control, and epidemiological and statistical methods in the study of antimicrobial resistance. His mentees have had over 450 publications from the time of his mentoring to the present. 101 publications have been mentee/mentor publications. Eighteen of 33 mentees are presently pursuing academic medical careers. In the initial five years of his K24, he successfully completed all proposed aims and mentored six faculty's career development awards. During the K24 period, he had over 46 publications of which 44 involved mentees. His current level of funding includes an NIH R01, an AHRQ R01, a CDC contract that has frequent requests for additional sub-contracts, a co-investigator on an NIH contract and two industry-sponsored research grants. Renewal of this K24 is critical to his desire to continue to mentor young investigators in the emerging areas of antibiotic-resistance, healthcare-associated infections and hospital epidemiology and to continue to evolve his research. He will take additional coursework to help move his research into the areas of cluster-randomized trials, genomic epidemiology, comparative effectiveness research and the study of the microbiome and antibiotic-resistance. The protected time is critical to Dr. Harris achieving these goals; without the K24 renewal, he will have to attend more on the infectious disease service and perform more hospital epidemiology and quality improvement in order to increase reimbursement directed towards his salary.