FY 13 Rodent Testing to Identify Pharma. for Substance Dependence

这项工作的目的是协助NIDA药物治疗和药物滥用医疗后果司(DPMCDA)成瘾治疗发现计划(ATDP)识别对治疗依赖有用的化学物质。被确定为目标的化合物将包括那些可能通过促进戒断和/或通过防止滥用(例如，通过药理或生理拮抗)而具有治疗效果的化合物。将使用五个体内模型来提供必要的信息，以促进化合物在这些计划中的进一步考虑：小鼠运动活性测试、大鼠药物辨别测试、大鼠条件性位置偏爱测试、小鼠应激诱导的可卡因条件性位置偏爱测试和大鼠自我给药测试。

The objectives of this work are to assist the NIDA Division of Pharmacotherapies and Medical Consequences of Drug Abuse (DPMCDA) Addiction Treatment Discovery Program (ATDP) in the identification of chemicals useful for treatment of dependence. The compounds targeted for identification will include those that may have therapeutic effects via facilitation of abstinence and/or by preventing abuse (e.g., via pharmacological or physiological antagonism. Five in vivo models will be used to provide information necessary to advance compounds for further consideration within these programs: The Mouse Locomotor Activity test, Rat Drug Discrimination test, Rat Conditioned Place Preference test, Mouse Stress-Induced Potentiation of Cocaine Conditioned Place Preference test, and Rat Self-administration test.