"Sleep Medicine Neurobiology and Epidemiology"

描述（由申请人提供）：该培训补助金在睡眠，其生理学和流行病学领域产生医生和博士后研究人员，以解决对我们社会的总体健康产生重大影响的问题。在科学研究和发现方面存在着巨大的需求和机会。风险和疾病检测/管理工作发展不足，睡眠医学的基础科学（睡眠生理学和昼夜节律）在生物学，神经网络和脑生理学的功能理解方面存在重大差距，以便为未来的治疗和预防工作提供信息。一个障碍是缺乏基础研究和面向患者的研究人员。该项目由退伍军人事务部医学中心睡眠障碍研究中心负责人金曼·P·斯特罗管理。睡眠障碍研究中心现在在医学院和克利夫兰其他四个学术医疗中心开展培训和研究项目。他和一个指导委员会（泰德·迪克博士，Richard Martin MD和Mark Chance PhD）批准加入该计划，并使用形成性培训委员会评估和组合技术监控学员的进展。展望未来，增加的维度是正式的系统生物学和生物信息学硕士。和博士生理学和生物物理学系的课程。16名教师导师是“培训师”，4名早期职业获奖教师是“初级培训师”;其他睡眠或基础科学的高级教师作为学员委员会成员参加。教师代表六个部门，每个部门都对睡眠，昼夜节律生物学，睡眠流行病学和/或临床调查有着固有的兴趣。该方案要求两名研究生学员有足够的资源，以追求先进的培训和两名研究生学员。我们提供临床科学硕士学位课程（CTST临床研究学者计划）和系统生物学的MD博士后学员的选择。对于所有学员的本质是个性化的，监督的研究培训;但所有学员满足从事教学工作，包括睡眠科学和医学，接触其道德，法律的，和社区问题，和职业发展。对于博士预科生，学位授予部门决定课程工作和论文进度，睡眠医学培训计划的临床医生作为博士生的一员。以马克思博士后学员还有一个培训委员会，负责评估进展和指导。所有受训人员都有一套工作，并对进展情况进行自我评估，作为半年一次评估的基础。有每周研讨会和小组与外部顾问和教师的年度务虚会。现在，医学、儿科学、生理学和生物物理学、神经科学、计算机科学、生物统计学和流行病学之间发生了强烈的相互作用。睡眠医学计划现在被认为是临床转化科学合作研究基础设施的一部分。

DESCRIPTION (provided by applicant): This training grant produces physician and post-doctoral investigators in the fields of sleep, its physiology and epidemiology to address problems that substantially effect the general health of our society. There are significant needs and opportunities for scientific research and discovery. Risk and disease detection/management efforts are poorly developed, and the basic science of sleep medicine (sleep physiology and circadian rhythm) has major gaps in functional understanding of biology, neural networks, and brain physiology in order to inform future treatments and prevention efforts. One barrier is a paucity of investigators in basic- and patient-oriented research. The program is managed by Kingman P. Strohl, who heads the Center for Sleep Disorders Research at the VA Medical Center. The Center for Sleep Disorders Research now reaches training and research programs in the School of Medicine and four other Cleveland academic medical centers. He and a steering committee (Ted Dick, PhD., Richard Martin MD, and Mark Chance PhD) approves admission to the program and monitors trainees' progress using formative trainee committee assessment and portfolio techniques. Looking forward, the added dimension is a formal Systems Biology and Bioinformatics M.S. and Ph.D. curriculum in the Department of Physiology and Biophysics. Sixteen faculty mentors are "trainers", with four early career awardees faculty as "junior trainers"; other senior faculty members in sleep or basic science participate as members of the trainee committee. Faculty represent six departments and each has an inherent interest in sleep, circadian biology, sleep epidemiology, and/or clinical investigation. The program requests two post-graduate trainees with sufficient resources to pursue advanced training and two graduate trainees. We provide options for a Master's Degree programs in Clinical Science (the CTST Clinical Research Scholars Program) and in Systems Biology for MD post-doctoral trainees. For all trainees the essence is individualized, supervised research training; but all trainees meet to engage in didactic work encompassing sleep science and medicine, exposure to its ethical, legal, and community issues, and career development. For pre-doctoral trainees, the degree-granting department determines course work and thesis progress, with a clinician from the Sleep Medicine Training Program as one member of the Ph.D. committee. Post-doctoral trainees also have a training committee which assesses progress and mentorship. All trainees maintain a portfolio of work with self-assessments of progress that forms the basis of bi-annual assessments. There are weekly seminars and an annual retreat of the group with outside advisors and faculty. A strong interaction now occurs among Medicine, Pediatrics, Physiology and Biophysics, Neuroscience, Computer Sciences, and Biostatistics and Epidemiology. The Sleep Medicine program is now a recognized as a part of the Case Clinical Translational Science Collaborative research infrastructure.