Multidisciplinary Training in TMJ Disorders/Pain: Integrating Basic, Translation

描述（由申请人提供）：哥伦比亚大学具有独特的定位，培养科学家和/或临床医生在颞下颌关节疾病和疼痛（TMJDP）方面的独立研究事业。通过过去5年的战略性招聘，哥伦比亚大学牙科医学院（CDM）现在已经拥有了一定数量的NIH资助的初级和中级教师，他们的研究直接在TMJDP进行。与此同时，医学和工程学校的多个关键招聘集群已经产生了分子遗传学、生物材料、化学工程和生物工程领域的主要科学家骨干，他们的专业知识与TMJDP相结合，产生了强大而新颖的方法。总的来说，我们的教师导师有超过28个NIH r01，为将在此资助下招募的学员提供广度和深度。在此之前，CDM已经建立了多个初级教员的职业发展记录，其中一个例子是一位牙医/科学家，他在新型TMJ干细胞/祖细胞方面的工作获得了NIDCR K99/R00的资助，并在2012年AADR和IADR会议上分别获得了哈顿奖的第一名。这个TMJDP培训项目建立了重要的合作伙伴关系，并利用了哥伦比亚大学目前可用的大量资源。跨学科研究是哥伦比亚大学的一项特别优势，目前在牙科、医学、工程、生物科学和公共卫生领域有合作。历史悠久的TMJ/口腔面部疼痛诊所（成立于1949年）不仅在纽约市，而且在纽约，新泽西，康涅狄格州和费城北部的周边地区治疗广泛的患者，为转化和临床研究提供了一个肥沃的平台。位于纽约市的哥伦比亚大学（Columbia University）通过为学生提供广泛的学习机会，吸引了大量具有不同学术、临床、社会和种族背景（包括未被充分代表的少数族裔）的学生。本次K12提案的总体目标是准备和培养科学家和/或临床医生成为TMJDP的独立研究人员。我们将建立一个可持续的招聘、指导和职业过渡（RMCT）渠道。我们将采取以学员为中心的方法，非常遵循哥伦比亚大学的传统，通过最大限度地提高每位学员的学习经验来关注每位学员。为响应本《FOA》，我们的内部指导委员会进行了SWOP分析（优势、劣势、机会和威胁），并咨询了我们内部和外部咨询小组的成员。因此，我们设置了以下3个培训轨道：遗传学/生理学，生物工程/再生和成像/生物力学。我们的长期目标，在这5年的资助之外，是继续一个成功和可持续的项目，在TMJDP和其他牙科和颅面研究领域培养独立的研究人员。

DESCRIPTION (provided by applicant): Columbia University is uniquely positioned to develop scientists and/or clinicians towards independent research careers in temporomandibular joint disorders and pain (TMJDP). Through strategic recruitment in the past ~5 years, Columbia University College of Dental Medicine (CDM) now has a critical mass of NIH funded, primary and secondary faculty members whose research is directly in TMJDP. In parallel, multiple clusters of key recruitments in medical and engineering schools have yielded cadres of leading scientists in molecular genetics, biomaterials, chemical engineering and bioengineering whose expertise, when integrated with TMJDP, generates powerful and novel approaches. Collectively, our faculty mentors have over 28 NIH R01s that offer both the breadth and depth to trainees that will be recruited on this grant. Prior to this FOA, the CDM has established a track record of career development of multiple junior faculty members, with one example of a dentist/scientist whose work in novel TMJ stem/progenitor cells has received NIDCR K99/R00 funding, in addition to recognition as 1st place Hatton Awardees separately at 2012 AADR and IADR Conferences. This TMJDP training program has built key partnerships and leveraged tremendous resources that are currently available at Columbia. Interdisciplinary research is a particular strength at Columbia, with existing collaborations among dentistry, medicine, engineering, biological science and public health. The long-standing TMJ/Orofacial Pain Clinic (est. 1949) treats a broad range of patients not only in New York City, but also surrounding areas of New York, New Jersey, Connecticut and Northern Philadelphia, offering a fertile platform for translational and clinical research. Columbia University in the City of New York attracts abundant candidates with diverse academic, clinical, social and ethnic background, including underrepresented minorities, by offering them a broad range of learning opportunities. The overall objective of this K12 proposal is to prepare and develop scientists and/or clinicians into independent research investigators in TMJDP. We will set up a sustainable pipeline of Recruitment, Mentorship and Career Transition (RMCT). We will take a trainee-centered approach, very much along the Columbia tradition to focus on each student by maximizing his/her own learning experience. In response to this FOA, our Internal Steering Committee has performed a SWOP analysis (Strengths, Weaknesses, Opportunities and Threats) and consulted members of our Internal and External Advisory Panels. Accordingly, we have set the following 3 training tracks: Genetics/Physiology, Bioengineering/Regeneration and Imaging/Biomechanics. Our long-term goal, above and beyond this 5-year grant, is to continue with a successful and sustainable program to develop independent research investigators in TMJDP and other areas of dental and craniofacial research.