Genomics

在遗传学和基因组研究的历史上，从来没有像今天这样令人兴奋的时刻。基因组技术每天都在进步，更好、更快、更便宜的方法正在以惊人的速度发展。因此，基因组发现也在以前所未有的速度前进。由Molly Bray博士和Jose Fernandez博士领导的NORC基因组核心(GC)通过为NORC研究人员提供关于肥胖和营养的遗传和基因组研究的先进方法，提供关键的能力来检查遗传变异和基因功能对肥胖结果的影响。自2000年成立以来，基因组学核心(以前称为遗传学核心)一直为研究样本的准备和储存以及DNA序列的表征提供服务。在过去的资金周期中，NORC基因组学核心支持了32名调查人员、25个联邦资助项目和9个试点项目，产生了55种出版物。通过新的合作和UAB最近收购的更多基因组学资源(如下所述)，我们现在有能力为我们的成员群提供更广泛的基因组学服务，包括全基因组基因分型、基因表达和甲基化阵列、低通量和高通量定制基因分型和基因表达，以及标准和下一代测序(NGS)。除了我们的技术能力，基因组学核心主管Bray博士和Fernandez博士不仅可以为基因组分析和分析的选择提供指导，而且还可以提供肥胖遗传学、干预反应表型和遗传混合物方面的专家。这一专门知识通过提供方法学和内容方面的专业知识，提高了基因组学核心的价值。

Never has there been a more exciting time in the history of genetics and genomics research than today. Genomic technologies are advancing on a daily basis, with better, faster, and cheaper methodologies being developed at an astounding rate. As such, genomic discovery is also advancing at an unprecedented pace. The NORC Genomics Core (GC), led by Drs. Molly Bray and Jose Fernandez, provides the critic^al capacity to examine the effects of genetic variation and gene function on obesity outcomes by making available advanced methodologies for genetic and genomic studies of obesity and nutrition for NORC investigators. Since its inception in 2000, the Genomics Core (formerly, the Genetics Core) has provided services for preparation and banking of study samples and the characterization of DNA sequence. In the past funding cycle, the NORC Genomics Core has supported 32 investigators, 25 federally funded projects, and nine pilot projects, resulting in 55 publications. Through new collaborations and expanded genomics resources recently acquired by UAB (described below), we now have the capacity to provide a wider range of genomics services to our member base, including whole genome genotyping, gene expression, and methylation arrays, low and high throughput custom genotyping and gene expression, and standard and next generation sequencing (NGS). Beyond our technological capabilities, the Genomics Core directors, Drs. Bray and Fernandez, can provide not only guidance on selection of genomic assays and analyses but are also experts in obesity genetics, intervention response phenotypes, and genetic admixture. This specialized knowledge enhances the Genomics Core's value by providing both methodologic and content expertise.