Investigation into the intervention of arterial thrombosis and atherosclerosis using shear sensitive nanoparticle drug delivery

在这个项目中，我们的目标是提供一种靶向治疗，抑制动脉粥样硬化，支架内再狭窄和血栓形成;病理特征是高剪切应力，由于在血管管腔减少。我们将应用微流体技术来表征脂质纳米胶囊，这些脂质纳米胶囊用抗活化血小板或VCAM-1的抗体标记，装载有抗血小板或免疫抑制药物，并且在高剪切应力条件下特别容易破裂。

In this project we aim to provide a targeted therapy that inhibits atherosclerosis, in-stent restenosis and thrombosis; pathologies characterized by high shear stress due to a reduction in the vessel lumen. We will apply microfluidic technology to characterize lipid nano-capsules that are tagged with antibodies against activated platelets or VCAM-1, loaded with anti-platelet or immune suppressive drugs and are prone to rupture specifically under high shear stress conditions.