Prenatal Under Nutrition and Mortality Through Age 63 Project

描述（由申请人提供）：1944-1945年的荷兰饥荒（“饥饿的冬天”）提供了一个独特的机会，以确定生命过程健康和福祉的早期生命决定因素。迄今为止，研究集中在20世纪60年代初18岁时接受检查的约45，000名新兵的健康和死亡率结果。这些人的饥荒暴露程度可以从出生地点和日期推断出来。现在要求提供资金，将政府来源的各种社会经济成果（就业，工资和残疾福利）与我们研究的人口联系起来。这项研究是流行病学家、人口统计学家和经济学家（芝加哥大学赫克曼博士）合作进行的。新链接的数据将使用最先进的流行病学和计量经济学方法进行分析，以可靠地识别，估计和解释整个生命周期中早期生命冲击的影响。这项工作将 整合目前分离的研究传统，从医学和社会科学，并导致更好地了解'胎儿编程'及其影响。

DESCRIPTION (provided by applicant): The Dutch Famine ('Hunger Winter') of 1944-1945 provides a unique opportunity to identify early life determinants of life course health and well-being. To date, studies have concentrated on health and mortality outcomes in ~45,000 army recruits who were examined at age 18 in the early 1960s. Famine exposure in these men can be inferred from place and date of birth. Funding is now requested to link a wide variety of socio-economic outcomes (employment, wages, and disability benefits) from government sources to our studied population. The study is collaboration between epidemiologists and demographers and economists (Dr. Heckman, University of Chicago). The newly linked data will be analyzed with state-of-the-art epidemiologic and econometric approaches to reliably identify, estimate, and interpret the effects of an early life shock throughout the lifecycle. This work will integrate currently separated research traditions from the medical and social sciences and lead to a better understanding of 'fetal programming' and its implications.