Program in Human and Molecular Genetics

描述（由申请人提供）：此申请是对贝勒医学院分子和人类遗传学博士前培训计划的5年续期支持的请求。分子与人类遗传学系遵循三个原则，指导贝勒医学院追求创新的生物医学：研究、教育和服务。该项目的任务是培养研究生掌握古典和现代遗传学的基础知识，并将这些原理应用于生物医学的创新。我们的目标是在强调研究和学术卓越的同时，为学生提供严格和系统的遗传学培训，并帮助他们成为下一代生物医学科学家中的领导者。目前该项目有75名博士生，我们预计每年将有12-16名新生在该系开始他们的研究生工作。教师导师的人数为66人，他们从事的研究项目涉及广泛的兴趣领域，包括人类遗传学、基因组学和人类疾病的分子基础、人类疾病的动物模型、微生物遗传学、发育、神经生物学、基因组稳定性和DNA复制。这些不同主题的共同主题是对遗传学的兴趣以及将研究结果应用于人类健康。进入该项目的学生在第一年的培训中学习课程并进行实验室实习。这些课程为学生提供了足够的背景知识来设计和分析基于基因的实验结果，并且轮转提供了个性化的研究经验。学生们还参加了在基因组时代负责任的研究行为和人类遗传学伦理方面的专业培训。第二年，学生参加资格考试，测试他们整合课程和文献知识的能力，以及设计实验研究项目的能力。然后，他们加入一个研究实验室，在其中一位教师导师的监督下进行一个研究项目。除了实验工作方面的训练外，学生还将学习如何分析他们的数据和撰写描述他们工作的论文，以及如何以合作和建设性的方式参与科学过程。论文项目最终在论文论文的准备和辩护。该项目获得博士学位的平均时间为5.8年，平均每位学生发表5.5篇论文，平均发表2.2篇第一作者论文。目前该基金的培训职位数量为8个，我们要求将其增加到12个，以增加受训者的数量和多样性，以配合培训教员数量的增加，并达到全国遗传学培训项目的平均水平。

DESCRIPTION (provided by applicant): This application is a request for a 5-year renewal of support for the Predoctoral Training Program in Molecular and Human Genetics at Baylor College of Medicine. The Department of Molecular and Human Genetics follows three principles that guide the pursuit of innovative biomedicine at Baylor College of Medicine: Research, Education and Service. The mission of this program is to train graduate students in the fundamentals of classical and modern genetics and in applying these principles to innovation in biological medicine. Our objectives are to provide students with rigorous and methodical training in genetics while emphasizing research and academic excellence, and to help them become leaders among the next generation of biomedical scientists. There are currently 75 predoctoral students in the program and we expect that 12-16 new students will initiate their graduate work in the department each year. The number of faculty mentors is 66 and they pursue research projects that span a wide range of interests, including human genetics, genomics, and the molecular basis of human diseases, animal models of human diseases, microbial genetics, development, neurobiology, genome stability, and DNA replication. The common theme of these varied topics is the interest in genetics and the application of the findings to human health. Students who enter the program spend the first year of their training taking courses and doing laboratory rotations. The courses provide students with sufficient background to design and analyze the results of genetic-based experiments and the rotations provide individualized research experiences. The students also participate in specialized training in the responsible conduct of research and in ethical aspects of human genetics in the genomic era. In the second year, students take a qualifying examination that tests their ability to integrate knowledge from courses and from the literature and to design an experimental research project. They then join a research laboratory in which they carry out a research project under the supervision of one of the faculty mentors. In addition to training in experimental work, students learn how to analyze their data and write papers describing their work, and how to participate in the scientific process in a collegial and constructive way. The thesis project culminates in the preparation and defense of a thesis dissertation. The average time to a PhD degree in the program is 5.8 years and the average number of publications is 5.5 per student, with 2.2 first-author papers on average. The current number of training positions on this grant is 8 and we are asking to increase it to 12 in order to increase the number and the diversity of our trainees, to match the increasing number of training faculty, and to match the national average among genetics training programs.