Southern California Clinical and Translational Science Institute

这一修订后的临床和转化科学奖（CTSA）申请将支持继续 洛杉矶盆地临床和转化科学研究所（CTSI）的发展。我们的愿景是 改善洛杉矶城市多样化和服务不足人口的健康状况，并通过这样做， 我们可以与他人分享的知识，以改善城市环境和特大城市的健康状况， 地球仪。为了实现这一愿景，我们与领先的学术、临床和 洛杉矶市中心的社区健康组织。我们正在将这种伙伴关系转变为 一个卓越的临床和转化科学研究所，专注于为多样化的城市居民提供更好的健康， 社区.我们为CTSI确立了四个主要目标：建立在许多独立优势的基础上， 创建一个高度重视临床和转化科学的综合学术之家;创建 新的翻译研究团队，并开展项目，利用我们独特的人口， 伙伴关系，以解决最好的科学机会和最重要的健康优先事项，我们的地方 改革教育和培训，以培养一批主要职业侧重于 临床和转化研究;并实施和传播我们所学到的，以改善我们的健康 通过区域和国家网络促进转化研究， 合作。为了实现这些目标，我们组建了一支卓越的领导团队， 通过CTSI：积极发展新的研究项目和团队的优秀资源， 强大的基础设施，以促进和支持基础，临床和社区研究，尖端 数据采集、综合、管理和分析方法;基础、 临床和社区研究人员使用远程教育，并专注于研究的多样化 社区;一种使用专业通信传播我们的研究结果的新方法 专业知识;和一个专业评估小组，以跟踪和评估我们的进展和影响。使用330万美元 在机构支持下，我们已经在将当地环境转变为 高度重视临床和转化研究的国家。我们展示了强大的能力， 支持令人兴奋的新研究，从实验室到我们的社区。随着CTSA和1870万美元的承诺， 在五年内，我们将扩大到一个功能齐全的研究所， 影响，以改善城市健康和推进临床和转化研究的学科。

This revised application for a Clinical and Translational Science Award (CTSA) would support the continued development of the Los Angeles Basin Clinical and Translational Science Institute (CTSI). Our vision is to improve health of the diverse and underserved population of urban Los Angeles and, in doing so, to gain knowledge that we can share with others to improve health in urban settings and megacities across the globe. In pursuit of that vision, we have established a unique partnership of leading academic, clinical and community health organizations in the urban heart of Los Angeles. We are transforming this partnership into a preeminent clinical and translational science institute focused on better heath for diverse, urban communities. We have established four main goals for the CTSI: build on many independent strengths to create an integrated academic home that places high priority on clinical and translational science; create new translational research teams and conduct projects that leverage our unique populations and partnerships to address the best scientific opportunities and most important health priorities of our local communities; transform education and training to create a cadre of people with a major career focus on clinical and translational research; and implement and disseminate what we learn to improve health in our local communities and advance translational research through regional and national networks and collaborations. To achieve these goals, we have assembled an exceptional leadership team that is creating through the CTSI: outstanding resources for active development of new research projects and teams, a robust infrastructure to promote and support basic, clinical and community research, cutting edge methodologies for data acquisition, integration, management and analysis; integrated training of basic, clinical and community researchers using distance education and a focus on research for the diverse communities; aa novel approach to dissemination of our findings using professional communications expertise; and aa professional evaluation group to track and evaluate our progress and impact. Using $3.3M of institutional support, we have already made significant progress in transforming our local environment to a home that highly values clinical and translational research. We demonstrate strong ability to generate and support exciting new research, from the bench to our communities. With a CTSA and a pledge of $18.7M of institutional support over five years, we will expand to a fully functional institute that will have a have a major impact to improve urban health and advance the discipline of clinical and translational research.