Interdisciplinary Training in Transplantation Biology

描述（由申请人提供）：移植是临床医学的一个快速扩展、具有挑战性的领域，具有治愈许多人类疾病的巨大潜力。这一领域为基础科学家和临床医生之间的富有成效的互动提供了令人兴奋的机会。 匹兹堡大学的Starzl移植研究所和医学院的部门提供了一个独特的学术环境，有利于在移植生物学方面对年轻的基础科学家和医生进行全面，广泛的培训，重点是免疫学，细胞和分子病理学。我们的跨学科移植生物学培训计划培训研究生和博士后研究人员，以帮助确保训练有素的研究人员可以在学术界，工业界和政府附属研究中担任领导角色。参与教师具有多样但互补的研究兴趣，富有成效的合作和培训年轻研究人员的承诺的成功记录，传授移植生物学技能。大多数方面都涵盖了，包括在免疫遗传学的专业知识，缺血再灌注损伤，抗原呈递细胞，T和B细胞生物学，耐受诱导，肝脏免疫学，移植感染性疾病，慢性排斥反应，复合组织移植，同种异体和异种识别的演变，异种移植和新的治疗免疫抑制剂/方案。培训计划的一个独特之处是，调查范围从无脊椎动物和啮齿动物到非人类灵长类动物和人类。 该培训计划的主要目标是培养优秀的，潜在的独立研究人员，能够解决移植生物学的基本问题，并配备适当的生存和职业发展技能。博士前学员是从匹兹堡大学医学院跨学科生物医学研究生培训计划的研究生中挑选出来的，他们表示有兴趣从事移植生物学的博士研究。根据这项培训补助金在最初供资期间取得的成功以及合格申请人的可得性， 在06年要求3名博士前学员，并在随后的几年为3名学员，分布在学生之间的第一，第二，第三或第四年的研究。具有MD，PhD或MD/PhD学位的博士后培训生将根据其突出的潜力进行选择，并将获得2年的支持。要求在06年为3名博士后学员提供支助，并在随后几年为3名学员提供支助。

DESCRIPTION (provided by applicant): Transplantation is a rapidly-expanding, challenging area of clinical medicine with great potential for the cure of many human diseases. This field provides exciting opportunities for productive interaction between basic scientists and clinicians. The University of Pittsburgh's Starzl Transplantation Institute and Departments in the School of Medicine provide a unique academic environment, conducive to the comprehensive, broad-based training of young basic scientists and physicians in transplantation biology, with an emphasis on immunology and cell and molecular pathology. Our Interdisciplinary Transplantation Biology Training Program trains graduate and postdoctoral researchers to help ensure that highly-trained investigators are available to assume leadership roles in academia, industry and government-affiliated research. Participating faculty with diverse but complementary research interests, a successful record of productive collaboration and a commitment to training young investigators, impart skills in transplantation biology. Most aspects are covered, including expertise in immunogenetics, aspects of ischemia-reperfusion injury, antigen-presenting cell, T and B cell biology, tolerance induction, liver immunology, biology of transplant infectious disease, chronic rejection, composite tissue transplantation, evolution of allo- and xenorecognition, xenotransplantation and novel therapeutic immunosuppressive agents/regimens. A unique feature of the Training Program is that investigations range from those in invertebrates and rodents to non-human primates and humans. The principal goal of this Training Program is to produce outstanding, potentially independent investigators, able to address fundamental questions in transplantation biology and equipped with appropriate survival and career development skills. Pre-doctoral trainees are selected from graduate students enrolled in the Interdisciplinary Biomedical Graduate Training Program at the University of Pittsburgh School of Medicine, who express interest in pursuing PhD research in transplantation biology. Based on the successes achieved during the initial funding period of this Training Grant and the availability of well-qualified applicants, support is requested for 3 pre-doctoral trainees in the 06 year and for 3 trainees in subsequent years, distributed between students in their 1st, 2nd, 3rd or 4th year of research. Postdoctoral trainees with MD, PhD, or MD/PhD degrees will be selected based on their outstanding potential and will be supported for 2 years. Support is requested for 3 postdoctoral trainees in the 06 year, and for 3 trainees in subsequent years.