The NYU Women's Health Study

描述（由申请人提供）：纽约大学妇女健康研究（NYUWHS）是一项前瞻性队列研究，纳入了1985-1991年在纽约市乳腺癌筛查诊所登记的14274名健康妇女。除了生殖因素、病史和生活方式的数据外，该研究还收集了所有参与者入组时的血清样本。在随后的乳腺癌筛查中，还收集了一半以上妇女的血清样本。所有研究参与者都可以获得DNA。迄今为止，纽约大学卫生研究所已经发表了170多篇论文，其中57篇是2010年以来发表的。NYUWHS发起或参与了乳腺癌、子宫内膜癌、结直肠癌、卵巢癌、肺癌、胰腺癌、肾癌、肝癌和非霍奇金淋巴瘤（NHL）的研究。所研究的暴露包括饮食、生殖因素、循环激素水平、饮食标志物、细胞因子和其他生物标志物。NYUWHS还参与了胰腺癌、非hl和胶质瘤的全基因组关联研究。最后，纽约大学健康研究中心获得了开展心血管疾病研究的资金，纽约大学健康研究中心的数据推动了新的统计方法的发展。此应用程序的目标是维护和增强研究的基础设施。具体目的是：1)通过主动和被动随访继续确定癌症病例；2)通过随访问卷更新暴露数据，包括饮食和户外散步；3)收集主要肿瘤部位（乳腺、结肠、子宫内膜、肺）的肿瘤块，根据分子亚型评估危险因素；4)收集和验证社区步行性数据。持续的随访预计将确定额外的1389例癌症病例，收集肿瘤街区将提高研究的价值，收集社区步行性数据也将提高研究的价值。纽约大学卫生学院有几个具体的优势。首先，在登记时收集的血清和DNA可供所有参与者使用，使生物库成为研究遗传变异、生物标志物和疾病风险之间关系的宝贵资源。其次，超过一半的参与者可获得重复血清样本，这对于评估和提高循环标记物的时间可靠性非常有价值。第三，虽然几个大型癌症队列在50岁时开始入组，但6659名NYUWHS参与者在入组/献血时年龄<50岁，这为研究年轻女性的癌症危险因素提供了机会。最后，纽约市是一个特别适合研究步行性的地方，因为不同社区的步行性差异很大。

DESCRIPTION (provided by applicant): The NYU Women's Health Study (NYUWHS) is a prospective cohort study of 14,274 healthy women who were enrolled in 1985-1991 at a breast cancer screening clinic in New York City. In addition to data on reproductive factors, medical history and lifestyle, the study collected serum samples from all participants at enrollment. Serum samples were also collected at subsequent breast cancer screening visits from over half the women. DNA is available for all study participants. To date, the NYUWHS has led to over 170 publications, 57 since 2010. The NYUWHS has initiated or participated in studies of cancer of the breast, endometrium, colorectum, ovary, lung, pancreas, kidney, liver and non-Hodgkin lymphoma (NHL). Exposures studied include diet, reproductive factors, and circulating levels of hormones, dietary markers, cytokines, and other biomarkers. The NYUWHS also participates in genome-wide association studies of pancreatic cancer, NHL, and glioma. Finally, the NYUWHS has been funded to conduct studies on cardiovascular disease and the NYUWHS data have motivated the development of new statistical methods. The objectives of this application are to maintain and enhance the infrastructure of the study. The specific aims are to: 1) continue cancer case ascertainment through both active and passive follow-up; 2) update exposure data, including diet and outdoor walking, through follow- up questionnaires; 3) collect tumor blocks for major cancer sites (breast, colorectal, endometrial, and lung) in order to assess risk factors according to molecular subtypes; 4) collect and validate data on neighborhood walkability. The continued follow-up is expected to identify an additional 1,389 cancer cases and the collection of tumor blocks will enhance the value of the study, as will the collection of data on neighborhood walkability. The NYUWHS has several specific strengths. First, serum collected at enrollment and DNA are available for all participants, making the biorepository a valuable resource to study associations between genetic variation, biomarkers, and disease risk. Second, repeat serum samples are available for over half of the participants and are very valuable to assess and improve temporal reliability of circulating markers. Third, while several large cancer cohorts started enrollment at age 50, 6,659 NYUWHS participants were <50 years of age at enrollment/blood donation, providing opportunities for the study of cancer risk factors among younger women. Finally, New York City is a particularly well-suited location for studies of walkability because there is a wide range in walkability across different neighborhoods.