Miami Treatment and Prevention Clinical Trials Unit (CTU)

描述(申请人提供)：迈阿密CTU计划继续为艾滋病毒/艾滋病的治疗和预防作出实质性贡献。CTU的结构是参与四个NIAID艾滋病毒/艾滋病临床研究网络，以提供高影响力的开创性研究，以及响应网络迅速出现的需求。为了实现这些目标，迈阿密反恐联盟打算通过持续不断的NIAID艾滋病毒/艾滋病研究资金，在25年来对艾滋病毒感染的治疗和预防作出重大贡献的基础上再接再厉。迈阿密地区是美国艾滋病毒/艾滋病发病率最高的地区之一，超过25年的临床试验设计和实施经验使迈阿密CTU在招募和留住受疫情严重影响的不同患者群体方面处于独特的地位。此外，科学专门知识的广度和深度使迈阿密CTU能够为NIAID艾滋病毒/艾滋病临床试验网络的科学议程做出贡献，以解决艾滋病毒/艾滋病研究的国家优先事项和迈阿密大都市受影响人口的需求。为了实现这些目标，我们打算通过整合迈阿密AACTG和IMPAACT小组以及预防艾滋病毒感染的综合艾滋病毒预防战略疫苗临床研究网络，在多个PI指导下建立迈阿密艾滋病毒/艾滋病临床试验股(CTU)。迈阿密CTU还将三个临床研究站点(CRS)整合到CTU中，以有效满足多样化患者群体和临床研究网络的需求。CTU和相关CRS的结构是为了促进协同效应和促进规模经济，从而为NIAID临床试验网络的研究议程带来切实的附加值。 相关性：迈阿密CTU的使命和总体目标与该网络保持一致，以减少疾病和感染的负担，并开发变革性的、假设驱动的临床研究，以测试治疗和预防艾滋病毒感染的创新方法。

DESCRIPTION (provided by the applicant): The Miami CTU plans to continue to make substantial contributions to the treatment and prevention of HIV/AIDS. The CTU is structured to participate in four NIAID HIV/AIDS Clinical Research Networks to deliver high impact ground breaking research, as well as, to respond to the rapidly emerging needs of the networks. To accomplish these goals the Miami CTU intends to build upon 25 years of major contributions to the treatment and prevention of HIV infection through continuous NIAID HIV/AIDS research funding. With one of the highest incidences of HIV/AIDS in the U.S. in the Miami metropolitan area, more than 25 years of experience in the design and implementation of clinical trials places the Miami CTU in a unique position to recruit and retain diverse patient populations that are severely impacted by the epidemic. Moreover, the breadth and depth of scientific expertise allow the Miami CTU to contribute to the scientific agenda of the NIAID HIV/AIDS clinical trials networks to address the national priorities for HIV/AIDS research and the needs of the Miami metropolitan affected population. To meet these goals, we intend to establish a Miami HIV/AIDS Clinical Trials Unit (CTU) under multiple PI direction through the integration of the Miami AACTG and IMPAACT groups and the Integrated HIV prevention strategies Vaccines to prevent HIV infections clinical research network. The Miami CTU also integrates three clinical research sites (CRS) into the CTU to effectively meet the needs of the diverse patient populations and of the clinical research networks. The CTU and associated CRS are structured to foster synergy and promote economy of scale, resulting in tangible added-value to the research agenda of the NIAID clinical trials network. RELEVANCE: The mission and overall goal of the Miami CTU aligns with the Networks to reduce the burden of disease and infection and to develop transformative, hypothesis-driven clinical studies that test innovative approaches for the treatment and prevention of HIV infection.