Animal MRI/Imaging Core

2014年10月1日至2015年9月30日期间，Animal MRI Core已对14个项目进行了MRI研究，其中8个项目正在积极成像，3个项目正在进行数据审查或手稿，3个项目发表了关于过去几年数据的论文。项目按主要研究者顺序列出： 1. Arai，Andrew; NHLBI方案H-0176，Beliveau研究员。大鼠心肌纤维化。实验性和年龄相关性纤维化、急性MI和慢性MI大鼠心脏的MRI显微成像。纤维化的显微成像细胞水平区域与显微镜和组织病理学的相关性。 2.新井，安德鲁，爱泼斯坦，史蒂文（华盛顿医院中心），同胞利平斯基。Arai Lab、AMRI Core和Stephen Epstein之间的合作。标记脂质体在小鼠心肌梗死中的成像。 3.布斯廷，迈克尔，国家癌症研究所的规定.研究员古泽。在2015年发表了一篇论文，该论文基于HMGN 5过表达转基因小鼠模型，从2009年至2011年在Core中成像心脏功能和解剖结构。 4.柯林斯，弗朗西斯，NHGRI方案G 03 -5，杜博斯研究员。在Lmna基因敲入小鼠中检查主动脉和肺动脉是否存在动脉导管未闭。 5. Finkel，Toren，NHLBI，方案H-0083，研究员Holmstrom：线粒体单向转运蛋白缺陷小鼠模型的舒张功能和右心室功能。我们已经完成了成像，并于2015年出版了手稿。叶院士：小鼠肺动脉高压模型。 6. Gahl，William，NHGRI方案G 04 -3，Malicdan和Mian研究员。心脏肥大小鼠模型的心脏功能和解剖学研究。目前正在进行中。 7. Kaplan，Mariana，NIAMS，方案A013-08-05，研究员Carmona-Rivera。银屑病模型中的炎症和心血管效应，与Mehta（NHLBI）实验室合作。 8. Mehta，Nehal，NHLBI，方案H-0275，研究员Ng：炎症和主动脉壁，银屑病小鼠模型中全身炎症对血管系统的影响。通过标记的巨噬细胞对炎症进行19 F成像。 9.莫斯，乔尔，NHLBI.亲爱的，托马斯，部门。皮肤科，USUHS，研究员彼得Klover，USUHS。NHLBI方案H-0028。TS-2结节性硬化模型小鼠。该小组正在准备2015年的手稿。 10. Moss，Joel，NHLBI方案H-0172 R1，研究员帕切科。目前正在审查关于CBML小鼠模型的数据，并进行3D身体成像以供手稿。 11.墨菲菲利普NIAID协议LMI 8 E在2015年发表了一篇关于ApoE小鼠模型心脏功能成像和2013年核心解剖结构的论文。 12. Sack，Michael，NHLBI方案H-0222-影像学研究集中于采用TAC手术（主动脉结扎术）的Parkin模型。目前正在审查一份手稿。 13. Segars，James，NICHD方案15-060。贝格沃德和夸列里研究员在Brx（AKAP 13）模型上进行的腕管功能和多巴酚丁胺应激测试，包括floxed和TetO系。 14.塔巴克，劳伦斯，NIDCR协议14-722，工作人员科学家贝雷斯。Galnt 1 KO小鼠最后一次成像于2014年，手稿于2015年发表。

The Animal MRI Core has performed MRI studies on 14 projects, of which 8 are actively imaging, 3 with data review or manuscript in progress, 3 with papers published on past years data, in the period from Oct. 1, 2014 to Sept 30, 2015. Projects are listed alphabetically by Principal Investigator: 1. Arai , Andrew; NHLBI protocol H-0176, fellow Beliveau. Rat Myocardial Fibrosis. MRI microimaging of rat heart in experimental and age-related fibrosis, acute MI, and chronic MI. Correlation of microimaging cellular level areas of fibrosis to microscopy and histopathology. 2. Arai, Andrew, Epstein, Steven (Washington Hospital Center), fellow Lipinski. Collaboration between Arai Lab, AMRI Core and Stephen Epstein. Imaging labeled liposomes in infarcted mouse myocardium. 3. Bustin, Michael, NCI protocol. Staff scientist Furusawa. Published a paper in 2015 based on a HMGN5 overexpressing transgenic mouse model imaged for cardiac function and anatomy in the Core from 2009-11. 4. Collins, Francis, NHGRI protocol G03-5, fellow Dubose. Examination of aorta and pulmonary artery for possible patent ductus arteriosus in Lmna knock-in mice. 5. Finkel, Toren, NHLBI, protocol H-0083, fellow Holmstrom : Diastolic function and right ventricular function in a mitochondrial uniporter deficient mouse model. We have completed imaging and a manuscript has been published in 2015. Fellow Ye: mouse model of pulmonary hypertension. 6. Gahl, William, NHGRI Protocol G04-3, fellows Malicdan and Mian. Cardiac function and anatomy in a cardiac hypertrophy mouse model. Manuscript currently in progress. 7. Kaplan, Mariana, NIAMS, protocol A013-08-05, fellow Carmona-Rivera. Inflammation and cardiovascular effects in a psoriasis model, in collaboration with the Mehta (NHLBI) lab. 8. Mehta, Nehal, NHLBI, protocol H-0275, fellow Ng: Inflammation and aorta wall, effect of systemic inflammation on vasculature in a psoriasis mouse model. 19F imaging of inflammation via labeled macrophages. 9. Moss, Joel, NHLBI. Darling, Thomas, Dept. of Dermatology, USUHS, fellow Peter Klover, USUHS. NHLBI protocol H-0028. TS-2 tuberous sclerosis model mice. The group is preparing a manuscript in 2015. 10. Moss, Joel, NHLBI protocol H-0172R1, fellow Pacheco. Currently reviewing data on a CBML mouse model with 3D body imaging for manuscript. 11. Murphy, Philip, NIAID protocol LMI8E. Have published a paper in 2015 on an ApoE mouse model imaged for cardiac function and anatomy in the Core in 2013. 12. Sack, Michael, NHLBI protocol H-0222- Imaging studies concentrating on a Parkin model with TAC surgery (aortic banding). A manuscript is currently under review. 13. Segars, James, NICHD protocol 15-060. Fellows Baig-Ward and Quaglieri. Cardac function and dobutamine stress testing on Brx (AKAP 13) model, including floxed and TetO lines. 14. Tabak, Lawrence, NIDCR protocol 14-722, staff scientist Beres. Galnt1 KO mice last imaged in 2014, manuscript published in 2015.