2015 International Molecular and Functional Pulmonary Imaging Workshop

 描述(由申请者提供)：本申请申请资助2015年国际分子和功能肺成像研讨会，为期三天的会议定于2015年11月12-14日举行。拟议中的研讨会将是在宾夕法尼亚大学举办的第五次此类研讨会。这些资金将用于支付专家演讲人和见习演讲人的旅费和住宿费。他们还将支持网播和公布讲习班的全部收益。正如我们过去所做的那样，我们计划通过网络现场直播研讨会，让不能亲自出席的感兴趣的人可以免费观看。肺部疾病是全球发病率和死亡率的一个巨大且不断增长的原因，影像领域已经成为诊断和治疗这些疾病的重要创新来源。现在，肺成像包括一系列用于功能、结构和分子评估的技术，包括生物、医学、物理、工程和化学等多个领域的研究人员正在迅速开发和完善。鉴于该领域的多样性和快速变化的性质，定期举办一次研讨会，将肺部成像科学家和临床医生聚集在一起，进行严格的思想交流是当务之急。据我们所知，我们的研讨会是唯一一个在专门用于肺部成像的空间中包含该领域的各个主要组成部分的场所。拟议研讨会的具体目的如下：(1)向肺部成像界通报结构和功能成像的最新发展；(2)探索严重肺部疾病潜在的基本细胞和分子机制，以及如何用尖端技术对其进行成像；(3)研究利用肺成像来评估治疗反应和这一目标所固有的挑战；(4)在网上直播整个会议过程，供非与会者自由访问，并允许观众实时参与研讨会的讨论。在这些组件中，有两个是肺成像研讨会迭代中的新组件。虽然在2013年的研讨会上，我们在会议记录中引入了分子肺成像，以补充我们对功能和结构方法的传统关注，但拟议的2015年会议将更彻底地专注于分子技术。它将包括对各种分子方法的讨论，包括PET和SPECT、超极化13C磁共振和光学成像，以及旨在促进新型分子探针开发的肺部生物学的演讲。明确侧重于成像技术以评估治疗反应也是研讨会的一个新方面。由于缺乏有效测量反应的成像方法，成功的肺部疾病治疗方法的发展一直受到阻碍。对这一问题的更大重视反映了为治疗评估开发更好的成像技术的紧迫性。

 DESCRIPTION (provided by applicant): This application requests funding to support the 2015 International Molecular and Functional Pulmonary Imaging Workshop, a three-day meeting scheduled for November 12-14, 2015. The proposed workshop will be the fifth of its kind held at the University of Pennsylvania. The funds will be used to cover travel and lodging expenses of expert and trainee speakers. They will also support the webcasting and publication of the entire proceeds of the workshop. As we have done in the past, we plan to broadcast the workshop live over the web to be freely accessed by interested parties who cannot physically attend. Pulmonary diseases are a massive and growing cause of global morbidity and mortality, and the field of imaging has become an important source of innovation in diagnosing and treating these pathologies. Pulmonary imaging now comprises a litany of techniques for functional, structural, and molecular assessment being rapidly developed and refined by investigators in numerous fields including biology, medicine, physics, engineering, and chemistry. In light of the diverse and fast-changing nature of the field, regularly holding a workshop that brings together pulmonary imaging scientists and clinicians for the rigorous exchange of ideas is imperative. To our knowledge, our workshops are the only venues that include each major component of the field in a space solely dedicated to pulmonary imaging. The specific aims of the proposed workshop are as follows: (1) inform the pulmonary imaging community about the latest developments in structural and functional lung imaging; (2) explore fundamental cellular and molecular mechanisms underlying serious lung diseases and how they can be imaged with cutting-edge techniques; (3) examine the use of pulmonary imaging for assessing therapeutic response and the challenges inherent to this objective; (4) broadcast the entire proceedings live over the web to be freely accessed by non- attendees and allow this audience to participate in workshop discussions in real time. Of these components, two are novel to this iteration of the pulmonary imaging workshop. While in our 2013 workshop we introduced molecular lung imaging to the proceedings to complement our traditional focus on functional and structural approaches, the proposed 2015 meeting will much more thoroughly focus on molecular techniques. It will include discussion of the whole range of molecular approaches, including PET and SPECT, hyperpolarized 13C MR, and optical imaging as well as talks on lung biology designed to spur the development of novel molecular probes. The explicit focus on imaging techniques to assess therapeutic response is also a new aspect of the workshop. The development of successful treatments for lung diseases has been stunted by a lack of imaging approaches for the effective measurement of response. A greater emphasis on this issue reflects the urgency of developing better imaging techniques for therapeutic assessment.