PILOT AND FEASIBILITY PROGRAM

UCSD/UCLA DRC的试点和可行性计划的使命是促进新研究者的发展，并为高风险糖尿病相关研究项目提供种子支持，重点是转化科学。该核心由Pinchas Cohen博士指导，他也是DRC副主任，也是国家糖尿病中心主任执行委员会的成员。在过去的十年中，该计划资助了41名科学家（过去5年中资助了28名，由ARRA补充DRC以支持P&F项目），其中90%以上是年轻的研究人员，其中95%以上仍然活跃在糖尿病研究中。这些研究人员获得了令人印象深刻的额外NIH支持的资助后记录，并在高影响力期刊上发表了大量论文。这些成就突出了我们机构中存在的年轻研究人员的特殊管道。P&F计划在此竞争性更新申请中的具体目标是继续：促进新兴糖尿病项目和未来的科学领导者;宣传，告知和参与糖尿病研究社区关于DRC P&F及其机会;促进和加快向外部资金的过渡;利用机构匹配支持，基础设施和技术实现P&F项目的成功;与其他机构的培训和研究计划协同;为新兴的糖尿病研究人员提供最新的研究技术和最先进的设施和服务;促进初级和高级科学家之间的合作研究;提高领导技能;并对P&F计划及其获奖者进行监督和计划审查。我们建议每年资助5个50，000美元的赠款，以支持收集足以支持ROI赠款申请的初步数据，重点是新的研究人员和转化研究。我们已经建立了一个广告，征求，审查，奖励和（如有必要）终止P&F项目的流程。该计划由多位经验丰富的外部评审员协助。我们从刚果民主共和国的所有机构中获得了大量的机构匹配支持，以支持有希望的提案。利用这种机构匹配支持，每年，我们将资助第六个，$50，000 P&F奖;每年一个补助金将被确定为“初级教师发展奖”，并将在第一年获得额外的$25，000，第二年还将获得$50，000的机构支持。最后，我们将支持P&F奖励，并提供10，000美元的信用额度用于DRC内核。.

The mission of the Pilot and Feasibility Program at the UCSD/UCLA DRC is to foster the development of new investigators and provide seed support for high-risk diabetes-related research projects with an emphasis on translational science. The core is directed by Dr. Pinchas Cohen, who is also DRC Associate Director, and a member of the National Diabetes Centers Directors Executive Committee. Over the last decade, the program funded 41 scientists (28 over the last 5 years, facilitated by an ARRA supplement to the DRC for the support of P&F projects), over 90% of which have been young investigators and more that 95% of them are still active in diabetes research. These investigators garnered an impressive post-funding record of additional NIH support and published a large amount of papers in high impact journals. These achievements underscore the exceptional pipeline of young investigators that exists in our institutions. Specific Objectives for the P&F Program in this competitive renewal application are to continue to: ¿promote emerging diabetes projects and future scientific leaders; advertise, inform and engage the diabetes research communities regarding the DRC P&F and its opportunities; facilitate and speed transition to external funding; leverage institutional matching support, infrastructure, and technologies towards the success of P&F projects; synergize with other institutional training and research programs; create access for emerging diabetes researchers to the latest research technologies and state-of-the-art facilities and services; foster collaborative research among junior and senior scientists; promote leadership skills; and implement oversight and programmatic review of the P&F program and its awardees. We propose to fund five $50,000 grants each year to provide support for collecting preliminary data sufficient to support ROI grant applications with a focus on newer investigators and translational research. We have established a process of advertising, soliciting, reviewing, awarding, and (if necessary) terminating P&F projects. This program is assisted by multiple experienced external reviewers. We leveraged substantial institutional matching support from all of the institutions that comprise the DRC, to support promising proposals. Using this institutional matching support, each year, we will fund a sixth, $50,000 P&F award; and one grant per year will be identified as a "junior faculty developmental award" and will receive an additional $25,000 in year one and will also receive institutional support of $50,000 for a second year. Finally, we will support P&F awards with $10,000 of credit towards use in DRC cores. .