2015 Stem Cells & Cancer Gordon Research Conference & Gordon Research Seminar

 第五届戈登干细胞与癌症会议将重点关注癌症干细胞的行为及其与其生态位的相互作用。随着肿瘤细胞克隆性进化的发生，人们对癌细胞异质性产生了极大的兴趣。已经寻求了许多新的疗法来对抗这种异质性的特定方面。将研究的肿瘤包括黑色素瘤、白血病、淋巴瘤、肌肉肿瘤、结肠癌、乳腺癌、鳞状细胞癌、髓母细胞瘤等。有兴趣了解正常干细胞和癌症生物学之间的相互作用，这也将是会议的目标。将在会议上探讨的主题将是检查癌症干细胞的多样性，因为它们调节转移，正常干细胞生物学的理解，包括表观遗传调节，以及衰老和癌症的理解，癌症干细胞生物学，包括克隆进化。治疗目标将是靶向癌症干细胞并检查它们的小生境。正常造血和干细胞在白血病的比较也将讨论。也将有一个与本次会议相关的GRS，允许学生和博士后研究员与该领域的专家一起探索癌症和干细胞的各个方面。在GRC的这些演讲应该让我们更好地了解癌症是如何产生的，以及利基相互作用的过程。

 DESCRIPTION (provided by applicant): The Fifth Gordon Conference on Stems Cells and Cancer will focus on understanding how cancer stem cells behave and interact with their niche. There is a tremendous interest in heterogeneity among cancer cells as clonal evolution occurs in tumors. A number of new therapies have been sought to counter particularly aspects of this heterogeneity. Tumors will be investigated including melanoma, leukemia, lymphoma, muscle tumors, colon cancer, breast cancer, squamous cell cancer, medullar blastoma, and others. There is an interest in understanding the interaction between normal stem cells and cancer biology and this will also be a goal of the meeting. Topics that will be explored at the meeting will be to examine diversity of cancer stem cells as they regulate metastasis, an understanding of normal stem cell biology including epigenetic regulation, and understanding of aging and cancer, cancer stem cell biology including clonal evolution. A therapeutic aim will be to target cancer stem cells and examine their niches. A comparison of normal hematopoiesis and stem cells in leukemia will also be discussed. There will also be a GRS associated with this conference, allowing students and postdoctoral fellows to explore aspects of cancer and stem cells with experts in the field. These talks at the GRC should allow us to have a better understanding of how cancer arises and the process by which the niche interacts.