Cancer Epidemiology Research Program (CE) (Project-008)

项目008--癌症流行病学研究计划 项目摘要/摘要 随着范德比尔特-英格拉姆癌症中心(VICC)基于人群的研究的显著增长， 原来的癌症流行病学、预防和控制方案现在分为两个更有重点的 程序。新成立的癌症流行病学(CE)研究计划，由魏征博士指导 舒晓鸥，医学博士，博士，寻求进行高影响力的研究，以提高对病因的理解 并确定癌症风险和预后的生物标志物，为癌症的发展提供信息 有效的癌症预防策略。CE计划大致分为四个主要的癌症研究 专题领域：1)分子和遗传流行病学；2)营养、生活方式和 癌症风险的环境因素；3)癌症生存的预后因素的调查；以及4) 国际研究和健康差距研究。 行政长官的主要优势之一在于建立和进行大型队列研究， 从223,000名研究参与者那里获得了广泛的暴露数据和生物素。行政长官成员也是 进行大型癌症病例对照研究。这些资源提供了基于人口的特殊领域 许多重要研究的实验室。行政长官成员站在识别基因和 生活方式因素和多种癌症的生物标志物，研究极大地促进了对癌症的认识 病因学和遗传学，有助于修改美国癌症协会的生活方式指南 乳腺癌幸存者，并启动了两项化学预防试验。这项研究与 VICC集水区，涉及该人口的多个部分参与，包括历史上的 代表不足的群体。行政长官还拥有大量国际研究组合，以检验科学假说 这在美国的研究中无法得到充分的调查，并在多个大型 癌症流行病学联盟。CE主持了三个由NIH资助的培训项目，并成功地促进了 多名初级调查员的职业发展。 来自五个部门和两所学校的26名计划成员获得了NCI 1100万美元的资助 以及150万美元的其他同行评议的癌症相关资金。在421份出版物中，58%是方案内出版物 63%是跨计划的。会员还与其他网站的调查人员合作出版了181份出版物 机构。

PROJECT 008 – CANCER EPIDEMIOLOGY RESEARCH PROGRAM PROJECT SUMMARY/ABSTRACT With a significant growth in population-based research at the Vanderbilt-Ingram Cancer Center (VICC), the original Cancer Epidemiology, Prevention and Control program is now divided into two more focused programs. The newly formed Cancer Epidemiology (CE) Research Program, directed by Wei Zheng, MD, PhD and Xiao-Ou Shu, MD, PhD, seeks to conduct high-impact research to improve understanding of the etiology and genetics of cancer and identify biomarkers for cancer risk and prognosis to inform the development of effective cancer prevention strategies. The CE program is broadly organized into four main cancer research thematic areas: 1) molecular and genetic epidemiology; 2) epidemiology of nutrition, lifestyle and environmental factors for cancer risk; 3) investigation of prognostic factors for cancer survival; and 4) international studies and health disparities research. One of the key CE strengths lies in the establishment and conduct of large cohort studies with extensive exposure data and biospecimens obtained from 223,000 study participants. CE members are also conducting large cancer case-control studies. These resources provide exceptional population-based field laboratories for many significant investigations. CE members are at the forefront of identifying genetic and lifestyle factors and biomarkers for multiple cancers, with research significantly advancing knowledge of cancer etiology and genetics, contributing to the modification of American Cancer Society’s lifestyle guidelines for breast cancer survivors, and launching two chemoprevention trials. The research is directly relevant to the VICC catchment area, involving participation by multiple segments of this population, including historically underrepresented groups. CE also has a large portfolio of international research to test scientific hypotheses that cannot be adequately investigated in U.S.-based studies and plays a leadership role in multiple large cancer epidemiology consortia. CE hosts three NIH-funded training programs and has successfully fostered the career development of multiple junior investigators. There are 26 program members from five departments and two schools with $11.0 M in NCI funding and $1.5M in other peer-reviewed cancer-related funding. Out of 421 publications, 58% are intra-programmatic and 63% are inter-programmatic. Members also have 181 collaborative publications with investigators at other institutions.