Conference on Physiological Bioenergetics: From Bench to Bedside

 描述（由申请人提供）：在过去的2- 30年中，线粒体执行多种功能以维持细胞内稳态变得显而易见，所有这些功能都与代谢和基因组程序密切相关，远远超出了简单地制造ATP。在过去的5-10年中，新的尖端技术，新的分子工具和神经靶向治疗方法的发展使得更准确和深入地探测线粒体功能成为可能，并极大地改变了生理条件下的生物能量学研究。我们对线粒体功能调节机制及其对细胞稳态的贡献的了解也在迅速扩大。然而，这些进展通常是在特定的病理或器官系统的背景下取得的，并不总是被研究不同病理的研究人员广泛认可。此外，在将线粒体测量转化为人类研究方面仍然存在很大的知识差距。“生理生物能量学-从实验室到床边”会议的目标是汇集研究跨学科生物能量学各个方面的专家，并在不同病理学的背景下分享他们的最新发现，并讨论推进“生物学”领域转化和临床研究的策略。 拟议会议的具体目标是： 1.汇集研究跨学科和不同病理学背景下生物能量学各个方面的专家，分享他们的最新发现并讨论策略 将“生物学”领域推进到转化和临床研究中。 2.为初级研究员、研究生和博士后研究员提供一个场地，以口头和海报展示的形式突出他们的研究。 3.促进跨学科的合作/对话，以了解癌症在人类健康和疾病中的作用。 4.为代表性不足的少数群体提供一个可以参与的论坛。 本次会议的主要吸引力将是其重点放在跨学科和特定病理学的基本线粒体机制上。本次会议将作为跨学科的桥梁， 允许调查人员之间分享知识和建立合作，否则他们可能 被限制在他们研究的学科/病理学范围内。最终，本次会议的目标是推进线粒体的研究，特别是在临床研究领域，并促进跨学科的合作/对话，以了解线粒体在人类健康和疾病中的作用。

 DESCRIPTION (provided by applicant): In the last 2-3 decades, it has become apparent that mitochondria perform a multitude of functions to maintain cellular homeostasis, all of which are intimately linked to both metabolic and genomic programs extending well beyond simply making ATP. New cutting edge technology, novel molecular tools and mitochondrially targeted therapeutics developed in the past 5-10 years have made it possible to more accurately and deeply probe mitochondrial function and have dramatically altered the study of bioenergetics under physiological conditions. Our knowledge of the mechanisms by which mitochondrial function is regulated and its contribution to cellular homeostasis is also rapidly expanding. However, these advances are generally made in the context of a specific pathology or organ system and are not always widely recognized by investigators studying a different pathology. Further, a great gap in knowledge still exists in translating mitochondrial measurement to human studies. The goal of the "Physiological Bioenergetics-from Bench to Bedside" meeting is to bring together experts studying varied facets of bioenergetics across disciplines and in the context of different pathologies to share their most recent findings and to discuss strategies to advance the field of "mitochondriology" into translational and clinical studies. The specific aims of the proposed conference are: 1. To bring together experts studying varied facets of bioenergetics across disciplines and in the context of different pathologies to share their most recent findings and to discuss strategies to advance the field of "mitochondriology" into translational and clinical studies. 2. To provide a venue for junior investigators, graduate students and post-doctoral fellows to highlight their research in the form of oral and poster presentations. 3. To catalyze collaboration/conversation across disciplines to understand the role of th mitochondrion in human health and disease. 4. To provide a forum in which underrepresented minorities can participate. The major appeal of this conference will be its focus on basic mitochondrial mechanisms that cross disciplines and specific pathologies. This meeting will serve as a cross disciplinary bridge, allowing the sharing of knowledge and the establishment of collaborations among investigators who may otherwise be confined within the discipline/pathology they study. Ultimately, the goals of this meeting are to advance the study of mitochondria, particularly in the realm of clinical studies and to catalyze collaboration/conversation across disciplines to understand the role of the mitochondrion in human health and disease.