Pittsburgh Older Americans Independence Center

描述（由申请人提供）：匹兹堡克劳德D的总体目标。胡椒老年美国独立中心（OAIC），自2004年以来资助，是为了解决迫切需要改善流动性，平衡，和福尔斯风险，无论是通过提高对他们的原因的理解，并通过预防和治疗干预措施的发展。通过这次更新，我们还将把我们的工作扩展到新的和高潜力的领域，并为我们的活动和核心带来一些创新。 我们未来五年的具体目标是： 第一章 促进对与年龄相关的移动性和平衡变化的原因、后果和治疗的多学科研究。 （二） 建立在我们的研究团队的卓越专业知识，将我们的工作扩展到两个新的高潜力领域：a）介导多种身体组织/细胞器（神经，肌肉，骨骼，脂肪;线粒体）之间相互作用的机制，以及它们对移动性和步态的影响;和B）卫生系统和社区（包括长期护理）采用干预措施，以提高移动性和平衡性 第三章 培训来自多个学科的年轻研究人员在一个充满活力的智力，协作的环境与我们成功的临床和转化科学研究所对齐的新的KL 2计划。 四、 作为调查人员，研究计划，机构，OAIC和公众的资源和合作伙伴。 我们的成就和未来的计划是建立在一套持久的基本信念和价值观：1）一个主题（流动性和平衡），这是有凝聚力的，但容纳了广泛的方法和需求，2）致力于多学科研究，3）一个稳定的组织，可以成长和发展，以及4）下一代的研究人员和领导者的严格准备。 为了实现这些目标，我们的OAIC围绕6个核心构建。除了领导和行政核心和研究职业发展KL 2组件，我们有一个试点和探索性研究核心，和3个资源核心：临床和人口成果核心，综合系统核心和数据管理，分析和信息学核心。在更新的第一年，我们将支持2名Pepper KL 2学者，4个试点项目和3个开发项目，以说明我们工作的范围和创新。

DESCRIPTION (provided by applicant): The overall goals of the Pittsburgh Claude D. Pepper Older American Independence Center (OAIC), funded since 2004, are to address the critical need to improve mobility, balance, and falls risk, both through improved understanding of their causes and through development of preventive and therapeutic interventions. With this renewal we also will extend our work into new and high potential areas and bring several innovations to our activities and Cores. Our specific aims for the next 5 years are to: 1) Promote multidisciplinary research into the causes, consequences and treatment of age-related changes in mobility and balance. 2) Build on the exceptional expertise of our research team to extend our work into two new high potential areas: a) the mechanisms that mediate interactions between multiple body tissues/organelles (nerve, muscle, bone, fat; mitochondria), and their impact on mobility and gait; and b) health system and community (including long-term care) adoption of interventions to enhance mobility and balance 3) Train young investigators from multiple disciplines in an intellectually vibrant, collaborative environment with a new KL2 program aligned with our successful Clinical and Translational Science Institute. 4) Serve as a resource and partner to investigators, research programs, institutions, OAICs and the public. Our accomplishments and future plans are built on a set of enduring fundamental beliefs and values: 1) a theme (mobility and balance) that is cohesive yet accommodates a broad range of approaches and needs, 2) a commitment to multidisciplinary research, 3) a stable organization that can grow and evolve, and 4) rigorous preparation of the next generation of investigators and leaders. To accomplish these aims, our OAIC is built around 6 cores. In addition to the Leadership and Administrative Core and Research Career Development KL2 Component, we have a Pilot and Exploratory Studies Core, and 3 Resource Cores: a Clinical and Population Outcomes Core, an Integrative Systems Core and a Data Management, Analysis and Informatics Core. In the first year of the renewal, we will support 2 Pepper KL2 Scholars, 4 pilot projects, and 3 developmental projects that illustrate the scope and innovation of our work.