Development of MRI-based Cerebral Oxygen Extraction Fraction

描述（由申请人提供）：本研究的广泛、长期目标是提高颅内动脉粥样硬化疾病（ICAD）的诊断和治疗。颅内动脉粥样硬化的存在导致脑血流动力学的改变，也使患者有中风的危险。众所周知，ICAD的患病率随着年龄的增长而增加，这表明随着人口老龄化，它将成为医疗保健费用的一个越来越大的负担。使用正电子发射断层扫描（PET）直接评估组织氧提取分数（OEF），可以直接了解颅外动脉粥样硬化（即颈动脉疾病）卒中的严重程度、进展和风险。颅内动脉粥样硬化引起更多局灶性颅内灌注压损失，并导致CBF、CBV、OEF的改变。在这项工作中，我们将开发一种新的MRI脉冲序列用于量化OEF，并验证其与PET的准确性和可靠性。

DESCRIPTION (provided by applicant): The broad, long term goal of this research is to improve the diagnosis and treatment of intracranial atherosclerotic disease (ICAD). The presence of intracranial atherosclerosis results in alterations in cerebral hemodynamics and also puts patients at risk for stroke. The prevalence of ICAD is known to increase with age indicating that is will be an increasing burden on healthcare cost with the aging of the population. Direct evaluation of tissue Oxygen Extraction Fraction (OEF) using positron emission tomography (PET) scans have provided direct insight into the severity, progression and risk of stroke in extra-cranial atherosclerosis (i.e. Carotid artery disease). Intracranial atherosclerosis induces a more focal loss of intracranial perfusion pressure and results in alterations in CBF, CBV, OEF. In this proposed work we will develop a new MRI pulse sequence for the quantification of OEF, verify its accuracy, reliability against PET.