Pharmacology Training: Bench to Bedside

描述（由申请人提供）：加州大学戴维斯分校在与药理学培训计划（PTP）相关的研究和培训方面拥有强大的多学科和协作环境。59个培训学院来自6个学院的22个系，已经存在广泛的合作互动（例如，许多是药理学-毒理学（PTX）研究生组的成员，现在是第37个年头）。PhTP包括教师培训师，顺利跨越学院，学术部门和中心。PTP的目标是为博士生提供将临床前机制治疗发现转化为临床试验所需的核心教育和研究培训。这个翻译PTP的所有必要的教育组成部分都是由协作教学和培训提供的。加州大学戴维斯分校的培训师资资金充足，有正在进行的疾病导向和治疗发现项目，其中一些有制药行业的合作伙伴。他们的重点范围从鉴定新的治疗分子靶点，制造或鉴定治疗分子，新的开发细胞靶向策略，免疫介导和干细胞临床前治疗，到在加州大学戴维斯分校美国国立卫生研究院资助的临床和转化科学中心（CTSC），美国国立卫生研究院指定的癌症中心和UCD卫生系统内进行的临床试验。加州大学戴维斯分校非常丰富和协作的整体科学环境，强大而众多的最先进的核心设施和中心将为学员提供出色的研究机会(例如，从化学的重点药物化学，成像分子（从单分子到体内），基因组学，分子/系统建模，干细胞中心，独特的动物模型（国家认可的小鼠中心，兽医学院和灵长类动物中心）和CTSC。培训教师的疾病目标涵盖广泛的范围，但包括心血管，神经科学，癌症和炎症性疾病的力量。所有PhTP学员将在现代生理学和药理学方面打下坚实的基础，包括药代动力学、药效学、药物毒理学、药物代谢、药物发现和转化、生物统计学和负责任的研究行为。PhTP还提供促进专业发展的技能培训。培训学院以前的学员在学术界和工业界都有非常成功的职业生涯。这个PhTP将为有动力的学生和研究员在转化临床前治疗方面提供一个令人兴奋的培训机会。

DESCRIPTION (provided by applicant): UC Davis has a strong multidisciplinary and collaborative environment in research and training related to this Pharmacology Training Program (PTP). The 59 Training Faculty are from 22 departments in 6 colleges, where extensive collaborative interaction already exist (e.g. many are members of the Pharmacology- Toxicology (PTX) Graduate Group, now in its 37th year). The PhTP includes faculty trainers that smoothly span colleges, academic departments and centers. The PTP objective is to provide predoctoral trainees with the core educational and research training required for translating pre-clinical mechanistic therapeutic discoveries into clinical trials. All of the educational component necessary for this translation PTP are provided by collaborative teaching and training. The training faculty are well-funded with ongoing disease- oriented and therapeutic discovery projects at UC Davis and some have pharmaceutical industry partners. Their foci range from identifying novel therapeutic molecular targets, making or identifying therapeutic molecules, novel developing cell targeting strategies, immune-mediated, and stem cell pre-clinical therapeutics, to clinical trials being conducted at the UC Davis NIH-funded Clinical and Translational Science Center (CTSC), NIH-designated Cancer Center, and within the UCD Health System. The very rich and collaborative overall science environment at UC Davis, powerful and numerous state-of-the-art core facilities and centers will provide trainees with outstanding research opportunities (e.g. spanning from Chemistry's emphasis on pharmaceutical chemistry, imaging molecules (from single molecule to in vivo), genomics, molecular/system modeling, stem cell center, unique animal models (nationally recognized mouse center, Veterinary School and Primate Center) and CTSC. The disease targets of the training faculty cover a broad spectrum, but include strength in cardiovascular, neurosciences, cancer, and inflammatory diseases. All PhTP trainees will develop a solid foundation in both modern physiology and pharmacology, including pharmacokinetics, pharmacodynamics, pharmacotoxicology, drug metabolism, drug discovery and translation, biostatistics and responsible conduct of research. The PhTP also provides training in skills that promote professional development. Previous trainees of the training faculty have had highly successful careers in both academia and industry. This PhTP will provide an exciting training opportunity for motivated students and fellows in translational pre-clinical therapeutics.