Integrative Lipid Metabolism, Inflammation, and Chronic Diseases

描述(由申请者提供)：此申请旨在更新T-32资助，重点是在脂类科学、炎症和慢性病领域对博士前学生进行培训。脂质代谢和炎症的紊乱是许多慢性疾病的发病机制的核心，包括动脉粥样硬化、狼疮、哮喘、糖尿病、代谢综合征、肥胖、肝脏骨质疏松症、终末期肾脏疾病和癌症，但目前还没有NHLBI博士前培训计划，专注于慢性疾病发病机制和治疗中的脂质科学。这一培训计划有14名导师，他们具有不同的背景和专业知识，他们在五个部门担任主要学术职务。正在申请资金，以支持对四名博士前实习生的培训，他们将获得维克森林大学文理研究生院六个研究生项目中的一个博士学位。这一培训计划是许多老牌研究人员自然地持续合作的结果，他们聚集在维克森林医学院市中心校区一栋最先进的研究大楼的一层楼里。导师们对脂代谢在慢性疾病发病机制中的作用有共同的研究兴趣，慢性疾病仍然是美国公民死亡和发病的主要原因之一。所有导师目前至少与一名其他导师合作，并且是NIH拨款的主要调查人员和/或计划、项目或中心拨款的项目负责人。培训将涉及一种综合的、多学科的方法，使用分子、细胞和整个动物实验。对学生的培训将包括严格的教学课程、研讨会、期刊俱乐部、计划项目会议、植物中心会议、负责任的研究和专业发展培训、参与尖端研究项目、拨款撰写、在地区和国家会议上的科学陈述以及组织一年一度的脂类科学小型研讨会。所有受训人员在获得T-32的初步支持后，都需要写一份博士前研究金申请书(即F31或AHA)。培训的重点领域包括：1)脂肪代谢的功能基因组学，2)脂肪沉积的活体成像，3)植物脂肪在慢性病发病和治疗中的作用，4)脂质的大分子组装，5)脂质运输生物学，以及6)在慢性病的发病和治疗中的生物活性脂质。每个重点领域都有至少两名教职员工，他们将以共同指导的关系参与研究生的培训和监督。还为注册分子医学和转化科学研究生项目的学生提供了转化研究轨道，多名导师有翻译研究项目供学生培训。完成我们培训计划的研究生将拥有知识、技能和培训，加入学术界、政府或行业的国家努力，减少美国公民因脂代谢紊乱和炎症引起的慢性疾病的痛苦和死亡。(摘要结束)

DESCRIPTION (provided by applicant): This application seeks to renew a T-32 grant focused on training of pre-doctoral students in the areas of lipid science, inflammation, and chronic diseases. Disturbances in lipid metabolism and inflammation are central to the pathogenesis of many chronic diseases including atherosclerosis, lupus, asthma, diabetes, metabolic syndrome, obesity, hepatosteatosis, end-stage renal disease, and cancer, but there are no NHLBI predoctoral training programs that focus on lipid sciences in the pathogenesis and treatment of chronic diseases. This training program has 14 mentors, with diverse backgrounds and expertise, who have primary academic appointments in five departments. Funds are being requested to support the training of four predoctoral trainees who are earning the PhD degree in one of six graduate programs of the Wake Forest University Graduate School of Arts and Sciences. This training program has resulted from the natural on-going collaboration of a number of established investigators who have been assembled onto one floor of a state-of-the-art research building on the downtown campus of the Wake Forest School of Medicine. Mentors have a common research interest in the role of lipid metabolism in the pathogenesis of chronic diseases that continue to be among the leading causes of death and morbidity of US citizens. All mentors are currently collaborating with at least one other mentor and are principal investigators on NIH grants and/or project leaders on Program Project or Center grants. Training will involve an integrated, multidisciplinary approach that uses molecular, cellular, and whole animal experimentation. Training for students will include rigorous didactic courses, seminars, journal clubs, Program Project meetings, Botanical Center meetings, responsible conduct of research and professional development training, participation in cutting-edge research projects, grant writing, scientific presentations at regional and national meetings and organization of an annual Lipid Sciences Mini-Symposium. All trainees are required to write a pre-doctoral fellowship application (i.e., F31 or AHA) after initial support on the T-32. Areas of training focus will include: 1) Functional genomics of lipid metabolism, 2) In vivo imaging of lipi deposition, 3) Botanical lipids in the pathogenesis and treatment of chronic diseases, 4) Macromolecular assembly of lipids, 5) Lipid transport biology, and 6) Bioactive lipids in the pathogenesis and treatment of chronic diseases. Each of these areas of focus contains at least two faculty members who will participate in the training and supervision of graduate students in a co-mentoring relationship. There is also a translational research track for students who enroll in the Molecular Medicine and Translational Science graduate program and multiple Mentors have translational research projects for student training. Graduate students completing our Training Pro- gram will have the knowledge, skills, and training to join the national effort in academia, government, or industry to reduce the suffering and death of US citizens from chronic diseases that result from disturbances in lipid metabolism and inflammation. (End of Abstract)