UAB Center for AIDS Research

描述（由申请人提供）：UAB CFAR的使命是支持UAB研究人员在美国和世界各地开展多学科的尖端研究，包括艾滋病毒和相关疾病的预防、发病机制、治疗、临床护理和社会心理表现。25年来，该中心在支持其成员的研究活动方面发挥了至关重要的作用，这些活动导致了范式转变的发现，包括：发现HIV-1准物种多样性，检测HIV-1， 血浆中的RNA，急性和慢性感染中的病毒动力学，7种目前批准的疗法的首次人体I期临床研究，HIV-1的人畜共患起源，以及直接使用结果研究数据为临床实践提供信息。战略规划活动将我们的科学议程集中在未来5年，以解决：艾滋病毒的发病机制，艾滋病毒在治疗时代的自然历史，药物发现和预防。CFAR的目标反映了这一现代议程，并进一步推动了我们对创新性、多学科艾滋病研究的承诺，包括：为艾滋病毒/艾滋病研究活动提供一个中心机构重点，强调艾滋病毒/艾滋病研究中心成员和更广泛的艾滋病毒/艾滋病研究界之间的有效沟通与合作。 2.通过鼓励跨学科研究，并通过提供关键的共享资源设施和行政和财政管理支持中心研究人员正在进行的研究计划的生产力提高。 3.使用强大的战略规划方法来确定新的研究机会和优先事项，与现有的CFAR计划保持一致，并促进新的研究计划，其中没有存在，但教师的兴趣和大学的能力是显而易见的。 4.为了鼓励年轻人的加入， 通过对年轻研究人员的指导计划和同行评审的发展赠款计划，建立了艾滋病毒/艾滋病研究计划的教师队伍。 5.促进教师招聘和项目开发，反映了亚拉巴马，美国和世界各地艾滋病毒/艾滋病研究的持续发展。UAB CFAR在刺激艾滋病毒/艾滋病研究方面的成功反映在校外资金从1988年的600万美元增长到目前的8600多万美元，自2009年以来招募了24名以上的艾滋病毒/艾滋病调查人员，高调出版物，以及获得杰出的机构支持。 .

DESCRIPTION (provided by applicant): The mission of the UAB CFAR is to support UAB investigators in the conduct of multidisciplinary, cutting edge research in the prevention, pathogenesis, therapeutics, clinical care, and psychosocial manifestations of HIV and related disorders in the community, within the US and around the world. For 25 years, the Center has played a vital role in supporting research activities of its members that have led to paradigm-shifting discoveries, including: the discovery of HIV-1 quasi-species diversity, detection of HIV-1 RNA in plasma, viral dynamics in acute and chronic infection, first-in-human phase 1 clinical studies of 7 currently approved therapies, the zoonotic origins of HIV-1, and the direct use of outcomes research data to inform clinical practice. Strategic planning activities have focused our scientific agenda over the next 5 years to address: HIV pathogeneses, the natural history of HIV in the treatment era, drug discovery, and prevention. The objectives of the CFAR reflect this modern agenda and further our commitment to innovative, multidisciplinary AIDS research, including: 1. Provision of a central institutional focus for HIV/AIDS research activities that emphasize effective communication and collaboration among CFAR members and the wider HIV/AIDS research community. 2. Enhancement of productivity of ongoing research programs by encouraging interdisciplinary research and by providing critical shared resource facilities and administrative and fiscal management support to Center investigators. 3. Use of robust strategic planning methods to identify new research opportunities and priorities that align with existing CFAR programs and foster new research programs where none are in existence but where faculty interest and University capacity is evident. 4. To stimulate the entry of junior and established faculty into HIV/AIDS research programs through mentoring programs for young investigators and by a peer-reviewed Developmental Grants Program. 5. To stimulate faculty recruitment and program development in areas that reflect the ongoing evolution of HIV/AIDS research in Alabama, the United States, and around the world. The success of the UAB CFAR in stimulating HIV/AIDS research is reflected in the growth in extramural funding from $6.0 million in 1988 to over $86 million currently, in the recruitment of more than 24 HIV/AIDS investigators since 2009, high profile publications, and in the garnering of outstanding Institutional support. .