2022 Synaptic Transmission GRC/GRS

项目摘要 突触是健康大脑中交流和信号处理的关键要素。 此外，突触在几种神经和精神疾病中受到严重干扰。这 提案要求支持关于突触传递的国际科学会议，作为 戈登研究会议(GRC)系列将在意大利巴尔加的文艺复兴托斯卡纳Il Ciocco举行。 在GRC之前，将举行针对研究生的戈登研究研讨会(GRS) 博士后研究员6月20日至21日在同一地点。我们将把所有高度重视的科学家聚集在一起 对突触功能感兴趣，但在不同水平(分子、细胞和系统)研究突触 级别)，从不同的角度(自下而上、自上而下)来看待它们，并使用不同的方法 分子生物学、超分辨率成像、3D和低温电子显微镜、光遗传学、亚细胞 电生理学、建模和许多其他方面)。会议系列的长期目标是：(1) 加深对突触传递的基本分子和细胞机制的了解，(2) 阐明突触传递如何塑造神经元网络活动，以及(3)将基础科学与 了解疾病过程的突触。我们建议建立在这一非常成功的战略的基础上 以及实施创新战略，以查明和支持以下方面的工作 代表少数族裔，并通过导师-学员计划吸引受训人员和知名科学家。 30位坚定的演讲者将代表突触传递研究的关键领域 与会者在意大利巴尔加举行了一场为期五天的紧张会议，会议环境类似于静修。节目就要开始了 与该领域的领导者冯国平举行全体会议，冯国平将谈论使用转基因 研究与自闭症相关的突触功能障碍。然后将举行八次会议，讨论突触 从突触前和突触后的角度进行的传递包括：结构、可塑性、信号、人工 突触网络，病理学，与突触周围星形胶质细胞的关系，以及突触的功能 复杂的系统。所有四天的简短演讲和晚间海报会议将允许以下人员广泛参与 实习生和初级教职员工。最后一次全体演讲将由罗布·马伦卡发表，他是 研究突触可塑性的人一直专注于药物成瘾。这与健康和疾病的相关性 申请量很大。尽管许多演讲将集中在基础科学上，但数据迄今- 对正在出现的突触病变的破坏性大脑障碍的影响包括 神经退行性疾病，如帕金森氏症和阿尔茨海默氏症，情绪障碍，精神分裂症， 自闭症谱系障碍、精神发育迟滞和药物成瘾。2020年突触传输GRC 将在未来十年对基础神经科学和与疾病相关的神经科学产生重大影响。

Project Summary Synapses are key elements of communication and signal processing in the healthy brain. Furthermore, synapses are severely perturbed in several neurological and psychiatric diseases. This proposal requests support for an international scientific meeting on Synaptic Transmission as part of the Gordon Research Conference (GRC) series to be held at the Renaissance Tuscany Il Ciocco in Barga, Italy. This GRC will be preceded by a Gordon Research Seminar (GRS) targeted towards graduate students and post-doctoral fellows on June 20-21 at the same location. We will bring together scientists who all are highly interested in synaptic function but examine synapses at different levels (molecular, cellular, and systems level), look at them from different perspectives (bottom-up, top-down), and use different approaches (molecular biology, super-resolution imaging, 3D and cryo-electron microscopy, optogenetics, subcellular electrophysiology, modeling, and many others). The long-term objectives of the conference series are (1) to increase understanding of the fundamental molecular and cellular mechanisms of synaptic transmission, (2) to elucidate how synaptic transmission shapes neuronal network activity, and (3) to link basic science on synapses to understanding disease processes. We propose to build on the highly successful strategy of this traditional conference as well as implement innovative strategies for identifying and supporting under- represented minorities, and engaging trainees and established scientists using a mentor-mentee program. Thirty committed speakers will represent critical areas of synaptic transmission research for ~150 participants for an intense five-day conference in a retreat-like setting in Barga, Italy. The program will begin with a plenary session from a leader in the field, Guo-Ping Feng, who will talk about using transgenic marmosets to study synaptic dysfunction related to autism. Eight sessions will then address synaptic transmission from both pre- and postsynaptic perspectives including: structure, plasticity, signaling, artificial synaptic networks, pathology, relationships to perisynaptic astroglia, and the function of synapses in complex systems. Short talks and evening poster sessions on all four days will permit broad participation by trainees and junior faculty members. The final plenary talk will be given by Rob Malenka, a leader in studying synaptic plasticity who has focused on drug addiction. The health and disease relevance of this application is substantial. Although many presentations will focus on basic science, the data have far- reaching implications for devastating brain disorders that are emerging as synaptopathies including neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, mood disorders, schizophrenia, autism spectrum disorders, mental retardation, and drug addiction. The 2020 Synaptic Transmission GRC will have a major influence shaping both basic and disease-related neuroscience across the next decade.