Inhibitory synaptic plasticity during learning

摘要 大脑区分偶然和有意义的神经回路是什么？ 让感觉和行为发生长期变化的环境投入？实验 证据表明，这种区别可以在皮质处理的最早阶段做出， 在初级感觉皮质。在这里，我们将使用高吞吐量、自动化的行为训练 以确定大脑皮层详细的神经回路是如何 在获得基于触觉奖励的联想的过程中发生了明显的变化。我们的初步数据 提示小白蛋白(PV)介导的突触抑制的长期修饰是 选择性地由感觉联想训练驱动，而不是被动感觉暴露，提供了一种 立足点，研究区分不同类型的 依赖经验的可塑性。利用活体钙成像，靶向电生理 录音和解剖分析，我们将确定具体的机制 神经亚型促进与学习相关的皮质柱重组。

Abstract What are the neural circuits by which the brain differentiates between incidental and meaningful environmental inputs to enable long-lasting changes in sensation and behavior? Experimental evidence indicates that this distinction may be made at the earliest stages of cortical processing, in primary sensory cortex. Here we will use high-throughput, automated behavioral training in freely-moving mice to determine how the detailed neural circuitry of the cerebral cortex is distinctly changed during acquisition of a tactile reward-based association. Our preliminary data indicate that long-lasting modifications in parvalbumin (PV)-mediated synaptic inhibition is selectively driven by sensory association training but not passive sensory exposure, providing a foothold to investigate the cellular circuitry that distinguishes between different types of experience-dependent plasticity. Using in vivo Ca imaging, targeted electrophysiological recordings and anatomical analyses, we will determine the mechanisms by which specific neural subtypes facilitate learning-related reorganization of the cortical column.