FASEB's "The RNA Associated Mechanisms Conference: In Immunity and Disease"

项目摘要 虽然只有一小部分哺乳动物基因组编码蛋白质编码信使RNA， mRNA的调节机制一直是大多数生物学家感兴趣的主要焦点。但据 越来越明显的是，大多数不表达mRNAs的哺乳动物基因组具有 表达非编码RNA（ncRNA）的潜力。这些机构的职能和监管机制 ncRNA才刚刚开始探索。虽然我们现在已经意识到了一些基本的方面， 长期以来，非编码RNA（lncRNA）的生物发生，大多数lncRNA的生理作用仍然是一个黑盒。快速 在了解控制免疫系统的各种机制方面已经取得了进展 发展，但所有的问题都没有得到回答。现在，研究人员有兴趣了解 非编码基因组（以及随后的lncRNA转录物）在免疫系统发育中的作用以及各种 免疫系统相关的病理生理学。 事实上，如果ncRNA是免疫系统发育和功能的强大驱动因素，那么问题就出现了， 这些ncRNA是否受到调控。最近的一系列发现表明，mRNA和lncRNA 经历各种修饰（m6 A、m5 C、RNA编辑、假尿苷化等）。这些修改具有 专门的作家和橡皮擦。很可能这些修饰中的一些控制RNA功能，类似于 磷酸化和泛素化控制蛋白质功能的方式。RNA修饰在免疫中的作用 系统监管已经得到了一些非常令人兴奋的证据的支持。例如，m6 A RNA修饰 已显示决定造血细胞分化、T细胞稳态和调节性T细胞（Treg） 功能这些RNA修饰的作用--单独或聚集--在控制肿瘤的发展中， 体内平衡期间的免疫系统或其在感染期间的反应需要集中讨论。 基于上述两个新兴的和令人兴奋的主题，例如非编码RNA生物学和 免疫系统的epitranscriptomics，我们计划在7月12日至17日举行FASEB科学会议， 2020年在爱尔兰都柏林的马拉希德大酒店。会议的主要目的是：（a）提供一个 一个强大的和公正的科学论坛，讨论RNA生物学研究的现状， （B）为受训者（学生和博士后）提供机会 研究人员）介绍他们的研究，并介绍职业发展机会，以及（c） 提供有利于开展合作研究的环境。

Project summary Although only a small portion of the mammalian genome encodes protein coding messenger RNA, the mechanism of regulation of mRNA has been the primary focus of interest for most biologists. However, it is becoming increasingly evident that the majority of the mammalian genome that does not express mRNAs has the potential to express non-coding RNAs (ncRNAs). The functionality and mechanism(s) of regulation of these ncRNAs are just beginning to be explored. Although we are now aware of some of the fundamental aspects of long non-codingRNA (lncRNA) biogenesis, the physiological role of most lncRNAs remains a black box. Rapid progress has been made in the understanding the various mechanisms that control immune system development, but all questions have not been answered. Now, researchers are interested in understanding the role of the noncoding genome (and ensuing lncRNA transcripts) in immune system development and various immune system related patho-physiologies. Indeed, if ncRNAs are robust drivers of the immune system development and function, the question arises how are these ncRNAs regulated. A very recent set of discoveries has now demonstrated that mRNAs and lncRNAs undergo various modifications (m6A, m5C, RNA editing, pseudouridylation, etc). These modifications have dedicated writers and erasers. It is likely that some of these modifications control RNA function, akin to the way phosphorylation and ubiquitination control protein function. The role of RNA modification in immune system regulation is already supported by some very exciting evidence. For example, m6A RNA modification has been shown to determine hematopoietic cell differentiation, T cell homeostasis and regulatory T cell (Treg) function. The role of these RNA modifications--individually or in aggregate--in controlling the development of the immune system during homeostasis or its response during infection demands a focused discussion. Based on the two emerging and exciting topics mentioned above, e.g. noncoding RNA biology and epitranscriptomics of the immune system, we have planned a FASEB scientific conference from July 12-17, 2020 at Malahide Grand Hotel, Dublin, Ireland. The major purposes of the meeting are: (a) To provide a robust and unbiased scientific forum for the discussion of the current status of RNA biology research in the context of the immune system, (b) To provide an opportunity for trainees (students and post-doctoral researchers) to present their research and be introduced to career development opportunities and, (c) To provide an environment conducive to the initiation of collaborative research.