2020 Immunometabolism in Health and Disease GRC

项目摘要/摘要 2020年戈登研究会议(GRC)关于健康和疾病中的免疫代谢，小标题 《免疫中的细胞代谢：基础和翻译》，将是细胞界面上的首个GRC 新陈代谢和免疫(或“免疫新陈代谢”)，这是免疫学中的一个前沿、新兴领域。近期 研究表明，细胞新陈代谢既是基本的机械驱动因素，也是可干预的因素。 治疗传染病、过敏性疾病和其他免疫介导性疾病。意识到新陈代谢 在免疫反应过程中被重新编程，生物能量和其他代谢物被重新用于 调节免疫功能导致了最近的范式转变。作为这个年轻的跨学科领域 为了加快这一进程，迫切需要召集专家和受训人员。为此，我们正在举行一次会议。 于2020年6月21日至26日在罗德岛州史密斯菲尔德的布莱恩特大学学习。我们正在组装国际产品 来自学术界和工业界的专家，研究细胞新陈代谢在髓系和髓系细胞编程中的作用 淋巴免疫细胞在免疫和疾病中的作用，从而有望引起富有成效的、高水平的讨论 和合作，以及职业生涯早期研究人员和实习生的浓厚兴趣。在这些人中 我们会议的具体目的是介绍前沿未发表的科学，讨论和解决 对当前该领域的争议进行评估，确定/确定该领域未得到满足的需求的优先顺序，刺激新的 协作，并为受训人员和早期调查提供一个舒适和富有成效的论坛 来学习和分享他们的发现。联席主席Michael Fessler博士和池宏博博士与 副主席(Jeffrey Rathmell博士和Kathryn Moore博士)和其他实地负责人计划了九次口头会议 促进免疫代谢领域的老牌领导者和新兴专家之间的对话，这些专家包括 职业生涯早期科学家的实习生：课程1-生物能量学在先天免疫中的再利用和简短的演讲。 第二节：淋巴细胞功能的新陈代谢编程。第三节--接受豁免权训练，并进行简短的演讲。 第四节--免疫中的类固醇。会议5-免疫和微生物区系作为新陈代谢疾病的驱动因素。 第六节：肿瘤微环境的免疫代谢。会议7-宿主防御中的新陈代谢，以及 简短的谈话。第八节：免疫代谢中的细胞命运。第九场会议--干预的新机会 论疾病中的免疫代谢。演讲者和讨论领导者是多样化和包容性的，包括 妇女(29%)、早期调查人员(16%)、代表性不足的少数群体(10%)和国际 来自美国以外五个国家的专家。我们这次会议的重点直接对接了 NIAID致力于推进对传染病、过敏性疾病和免疫介导性疾病的可干预见解，我们 我们荣幸地邀请NIAID管理部门的成员作为与会者。我们的会议议程涉及不同的问题 免疫中髓系细胞和淋巴细胞的免疫与代谢的相互作用 介导性疾病，包括感染、过敏、自身免疫、癌症、动脉粥样硬化、肥胖和糖尿病。

Project Summary/Abstract The 2020 Gordon Research Conference (GRC) on Immunometabolism in Health and Disease, subtitled `Cellular metabolism in immunity: basic and translational', will be the inaugural GRC on the interface of cellular metabolism and immunity (or “immunometabolism”), a cutting-edge, emerging field in immunology. Recent studies indicate that cellular metabolism serves as both a fundamental mechanistic driver of and intervenable therapeutic target in infectious, allergic, and other immune-mediated diseases. The realization that metabolism is reprogrammed during the immune response and that bioenergetic and other metabolites are `repurposed' to modulate immune functions has led to a recent paradigm shift. As this young and interdisciplinary field accelerates, there is a critical need to convene experts and trainees alike. To this end, we are holding a meeting at Bryant University in Smithfield, Rhode Island from June 21–26, 2020. We are assembling international experts, both from academia and industry, on the role of cellular metabolism in the programming of myeloid and lymphoid immune cells in immunity and disease, and thus expect to foment productive, high-level discussions and collaborations, as well as significant interest among early-career investigators and trainees. Among the Specific Aims of our meeting are presentation of cutting-edge unpublished science, discussion and resolution of current controversies in the field, identification/prioritization of unmet needs in the field, stimulation of new collaborations, and provision of a comfortable and productive forum for trainees and early-stage investigations to learn and share their findings. The Co-Chairs, Drs. Michael Fessler and Hongbo Chi, in consultation with the Vice Chairs (Drs. Jeffrey Rathmell and Kathryn Moore) and other field leaders, have planned nine oral sessions to promote dialogue among established leaders in immunometabolism and emerging experts ranging from trainees to early-career scientists: Session 1 - Repurposing of Bioenergetics in Innate Immunity and Short Talks. Session 2 - Metabolic Programming of Lymphocyte Function. Session 3 - Trained Immunity, and Short Talks. Session 4 - Sterols in Immunity. Session 5 - Immunity and Microbiota as a Driver of Metabolic Disease. Session 6 - Immunometabolism of the Tumor Microenvironment. Session 7 - Metabolism in Host Defense, and Short Talks. Session 8 - Cell Fate in Immunometabolism. Session 9 - Emerging Opportunities for Intervening upon Immunometabolism in Disease. The speakers and discussion leaders are diverse and inclusive, including women (29%), early-stage investigators (16%), underrepresented minority groups (10%) and international experts from five countries outside the US. The focus of our conference directly meets the mission and goals of NIAID towards advancing intervenable insights into infectious, allergic, and immune-mediated diseases, and we are honored to invite members of NIAID administration as attendees. Our meeting agenda addresses diverse topics related to the crosstalk between immunity and metabolism in myeloid and lymphoid cells in immune- mediated diseases, including infection, allergy, autoimmunity, cancer, atherosclerosis, obesity, and diabetes.