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Defining renal S1P/sPRR/AT1R pathway in salt-sensitive hypertension

Defining renal S1P/sPRR/AT1R pathway in salt-sensitive hypertension
盐敏感性高血压肾 S1P/sPRR/AT1R 通路的定义
批准号：
9888044
负责人：
Tianxin Yang
金额：
$0.0万
依托单位：
VA SALT LAKE CITY HEALTHCARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
已结题
起止时间：
2020-10-01 至 2024-09-30
来源：
https://reporter.nih.gov/project-details/9888044
关键词：
AddressAntihypertensive AgentsAttenuatedBindingBiological MarkersBiological ProcessBlood PressureCardiovascular DiseasesChronic Kidney FailureDataDevelopmentEnzymesEquilibriumExtracellular DomainFluid BalanceGenerationsGoalsHypertensionInbred Dahl RatsInjury to KidneyKidneyMediatingModelingPathogenesisPathway interactionsPeptide HydrolasesPharmacologyProductionRattusReceptor InhibitionReceptor SignalingReceptor, Angiotensin, Type 1RegulationRenal tubule structureReninRenin-Angiotensin SystemRenin-Angiotensin-Aldosterone SystemReportingRoleTertiary Protein StructureTestingWaterepithelial Na+ channelhuman diseasehypertension treatmentinhibitor/antagonistinsightmemberneutralizing antibodynovelreceptorsalt sensitivesalt sensitive hypertensionsite-1 protease

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中文摘要
翻译
肾素-血管紧张素-醛固酮系统在高血压发病中的重要作用 高血压的突出特点是广泛使用其抑制剂治疗高血压。 目前的提案将解决肾部位-1蛋白/可溶性肾素(PRO)的作用 盐敏感型高血压发病机制中的受体。这项提议有可能 促进我们对高血压的基本机制的认识，也有助于 确定抗高血压治疗的新靶点。
英文摘要
The important role of renin-angiotensin-aldosterone system in the pathogenesis of hypertension is highlighted by the wide use of its inhibitors for treatment of hypertension. The current proposal will address the role of renal site-1 protease/soluble (pro)renin receptor in pathogenesis of salt-sensitive hypertension. The proposal has the potential to advance our understanding of the fundamental mechanism of hypertension and also to identify a novel target for antihypertensive therapies.
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会议论文
Adipose-derived sPRR controls circadian rhythm of blood pressure through inhibition of renal NCC activity
  • 批准号：
    10522511
  • 项目类别：
  • 资助金额：
    $63.07万
  • 财政年份：
    2022
  • 负责人：
    Tianxin Yang
  • 依托单位：
    UNIVERSITY OF UTAH
Adipose-derived sPRR controls circadian rhythm of blood pressure through inhibition of renal NCC activity
  • 批准号：
    10636885
  • 项目类别：
  • 资助金额：
    $58.66万
  • 财政年份：
    2022
  • 负责人：
    Tianxin Yang
  • 依托单位：
    UNIVERSITY OF UTAH
BLR&D Research Career Scientist Award Application
Defining renal S1P/sPRR/AT1R pathway in salt-sensitive hypertension
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