Animal Structure and Function

概述 动物结构和功能模块将为最先进的结构和功能动物测试提供新的集中空间，由一名专门的动物护理技术员进行测试，并培训调查人员及其工作人员使用新设备。近年来，眼科进行动物结构和功能测试的教职员工数量迅速增加。有了如此多的研究人员，就有了令人信服的经济和后勤理由，可以最大限度地减少科学研究中的动物数量。利用眼睛成像方法在活体动物身上进行纵向观察，可以大大减少在实验的不同时间点牺牲动物的需要。此外，视网膜成像设备的高成本使得复制视网膜成像设备的成本高得令人望而却步。该核心模块提供一系列成像和功能测试服务，并购买了配备mfERG和ERG设置的Micron III动物成像系统，以及安装在新的中央实验室中的光谱域光学相干层析成像仪器，使我们的研究人员能够最有效地利用他们的时间和资源。此外，它还将利用几个核心实验室(如Weinreb博士、Silva博士、Bartsch博士和Zhang博士)在工程、计算和成像方面的专业知识，以及UCSD Jacobs工程学院、国家显微和成像研究中心和生物工程系(Bartsch博士所属的)的国际声誉。总而言之，动物结构和功能模块将提供一套简化的工具，许多教师可以根据需要使用这些工具进行动物模型验证和疾病模型分析：OCT、FA、ICG、HRA、多焦点ERG测试和一系列眼睛成像服务。该模块由张博士和巴奇博士领导，他们的活体成像和功能分析专业知识和知识是无价之宝。

OVERVIEW The Animal Structure and Function Module will provide new centralized space for state-of-the-art structural and functional animal testing with a dedicated animal care technician to conduct the testing and to train investigators and their staff on the use of the new equipment. The recent growth in the number of faculty in the Department of Ophthalmology conducting animal structure and functional testing has grown rapidly in recent years. With this critical mass of investigators, there are compelling financial and logistical reasons to minimize the number of animals in scientific studies. The use of ocular imaging methods that enable longitudinal observations in a living animal can greatly reduce the need to sacrifice animals at different time points in an experiment. In addition, the high cost of retinal imaging devices has made it prohibitively expensive to duplicate retinal imaging equipment. This core module provides a range of imaging and functioning testing services and with the purchase of a Micron III Animal Imaging System with mfERG and ERG setup and a spectral domain optical coherence tomography instrument housed in a new centralized laboratory, allow our researchers to make most efficient use of their time and resources. Moreover, it will leverage the engineering, computing and imaging expertise of several core laboratories (e.g. Drs. Weinreb, Silva, Bartsch and Zhang) and the international reputation of the UCSD Jacobs School of Engineering and National Center for Microsocpy and Imaging Research and Department of Bioengineering (of which Dr. Bartsch is affiliated). In summary, the Animal Structure and Function Module will provide a streamlined set of tools that many faculty use on an as-needed basis for animal model validation and disease model profiling: OCT, FA, ICG, HRA, multi-focal ERG testing, and a range of ocular imaging services. This module is led by Drs. Zhang and Bartsch, whose in vivo imaging and functional analysis expertise and knowledge are invaluable assets.