The genetics of hepatosplenic T cell lymphoma
The genetics of hepatosplenic T cell lymphoma
批准号:
8880794
负责人:
Sandeep Dave
金额:
$21.71万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-04-01 至 2017-03-31
关键词:
A MouseAge of OnsetBehaviorBurkitt LymphomaClinicalDNA Sequence AlterationDataDiseaseEventFormalinGeneticGoalsHematologic NeoplasmsHereditary DiseaseHumanImmunoblastic LymphadenopathyIncidenceInstitutionKnock-outKnockout MiceLesionLiverLymphomaMethodsMolecularMusMutationNon-Hodgkin&aposs LymphomaNormal tissue morphologyParaffin EmbeddingPathogenesisPatientsPeripheralRNA SequencesRecurrenceResearchRoleSpleenT-Cell LymphomaT-LymphocyteTissuesWorkbasechemotherapyexome sequencinggenetic profilinglarge cell Diffuse non-Hodgkin&aposs lymphomamouse modelnew therapeutic targetnext generation sequencingnovel therapeuticspublic health relevancetargeted treatmenttherapeutic targettranscriptome sequencingtumor
中文摘要
描述(申请人提供):肝脾T细胞淋巴瘤是一种罕见但致命的疾病。发病年龄中位数为35岁,预期中位生存期不到两年。人们对这种疾病背后的基因变化知之甚少。在这项建议中,我们试图通过对人类原发肿瘤和唯一已知的疾病小鼠模型进行外显子组和RNA测序来定义疾病的遗传学。
英文摘要
DESCRIPTION (provided by applicant): Hepatosplenic T cell lymphoma is a rare, but lethal disease. The median age of onset is 35 and the expected median survival is less than two years. Very little is known about the genetic alterations underlying this disease. In this proposal we seek to define the genetics of the disease through exome and RNA sequencing of both primary human tumors and from the only known mouse model of the disease.
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海外基金