13th International Workshop on Radiation Damage to DNA

描述（由申请人提供）：本申请请求支持将于2014年6月14日至6月18日在剑桥的马萨诸塞州理工学院举行的第13届DNA辐射损伤国际研讨会。这将是非常成功的一系列独特的跨学科讲习班中的第十三次，这些讲习班汇集了物理学，化学，生物学和医学领域的领先专家，他们有兴趣了解电离辐射对DNA的影响，并将研究想法转化为预防，诊断和治疗的临床和公共卫生成果。与会者，限于150人，将来自不同的学术和研究机构，将包括研究生，博士后研究员，和早期职业生涯和高级科学家。该计划的一个独特之处是其主题的广度，从DNA中电离辐射的物理能量沉积到最终的生物学结果。讲习班共分15次会议，其中包括两次主旨演讲和两次海报展示，介绍了一些新的专题，如空间辐射生物学、辐射生物学的表观遗传学、放射治疗中的合成致死性、治疗性辐射抑制剂和高Z纳米粒子的放射增敏作用，以及低剂量辐射的生物影响。讲习班还讨论了辐射径迹、分子损伤和DNA修复的物理学和建模方面的最新发展;辐射引起的DNA氧化的化学; DNA成簇损伤和染色质损伤的化学机制和生物后果;辐射引起的DNA双链断裂和成簇损伤的修复;真实的研究DNA修复的新工具;以及一个纪念研讨会，以荣誉辐射化学生物学的先驱克莱门斯·冯·桑塔格。研讨会形式的亲密性促进了对DNA损伤产生机制的讨论，这些损伤的最终生物学后果，以及疾病预防，诊断和治疗的途径。虽然重点涵盖物理学，化学和生物学，但本次会议的一个重要目标是减少学科两极分化，激发新的跨学科思维和实验方法。沿着为促进正式和非正式讨论而组织的特邀演讲和海报会议，讲习班的结构强调年轻研究人员的参与，在每次会议上为研究生、博士后研究员和初级教师做口头演讲，并通过指导和与高级研究人员建立联系来鼓励他们的专业发展。

DESCRIPTION (provided by applicant): This application requests support for 13th International Workshop on Radiation Damage to DNA to be held at the Massachusetts Institute of Technology in Cambridge, MA, from June 14 through June 18, 2014. This will be the thirteenth in a highly successful series of uniquely interdisciplinary workshops that bring together the leading experts in physics, chemistry, biology and medicine who have an interest in understanding the effects of ionizing radiation on DNA and in translating the research ideas to clinical and public health outcomes in prevention, diagnosis and therapy. The participants, limited to 150, will be from diverse academic and research institutions and will include graduate students, postdoctoral fellows, and early-career and senior scientists. A unique feature of this program is its breadth of topics ranging from physical energy deposition of ionizing radiation in DNA through to the ultimate biological outcome. In 15 sessions with two Keynote Lectures and two poster sessions, the Workshop introduces new topics such as the biology of space radiation, the epigenetics of radiation biology, synthetic lethality in radiotherapy, therapeutic radiomitigators and radiosensitization by high-Z nanoparticles, and the biological impact of low-dose radiation. The Workshop also addresses the latest developments in the physics and modeling of radiation tracks, molecular damage and DNA repair; the chemistry of radiation-induced DNA oxidation; the chemical mechanisms and biological consequences of clustered DNA damage and damage to chromatin; repair of radiation-induced DNA double-strand breaks and clustered lesions; new tools for studying DNA repair in real time; and a memorial symposium to honor a pioneer in radiation chemical biology, Clemens von Sonntag. The intimacy of the Workshop format promotes discussion of the mechanisms involved in the production of DNA lesions, the ultimate biological consequences of those lesions, and pathways to disease prevention, diagnosis and therapy. Although the focus spans physics, chemistry and biology, an important goal of this meeting is to decrease polarization by discipline and stimulate new, interdisciplinary thinking and experimental approaches. Along with invited presentations and poster sessions organized to promote formal and informal discussions, the Workshop structure emphasizes the participation of young investigators with an oral presentation in each session for graduate students, postdoctoral fellows and junior faculty, and encourages their professional development by mentoring and networking with senior researchers.